Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3923732..3924369 Replicon chromosome
Accession NZ_CP042596
Organism Granulicella sp. WH15

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FTO74_RS16270 Protein ID WP_162539083.1
Coordinates 3924046..3924369 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FTO74_RS16265 Protein ID WP_162539082.1
Coordinates 3923732..3924049 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTO74_RS16245 3919210..3919980 + 771 WP_162539078.1 MBL fold metallo-hydrolase -
FTO74_RS16250 3920582..3921517 - 936 WP_162539079.1 LysR family transcriptional regulator -
FTO74_RS16255 3921754..3922002 + 249 WP_162539080.1 helix-turn-helix domain-containing protein -
FTO74_RS16260 3921999..3923231 + 1233 WP_162539081.1 site-specific integrase -
FTO74_RS16265 3923732..3924049 - 318 WP_162539082.1 helix-turn-helix domain-containing protein Antitoxin
FTO74_RS16270 3924046..3924369 - 324 WP_162539083.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FTO74_RS16275 3924578..3924841 + 264 WP_162539084.1 prevent-host-death protein -
FTO74_RS16280 3924838..3925266 + 429 WP_162539085.1 nucleotide-binding protein -
FTO74_RS19405 3925721..3926458 + 738 WP_174242236.1 ATP-binding domain-containing protein -
FTO74_RS16290 3926544..3926927 + 384 WP_162539086.1 hypothetical protein -
FTO74_RS16295 3926979..3927758 - 780 WP_162539087.1 LytTR family DNA-binding domain-containing protein -
FTO74_RS16300 3927755..3928858 - 1104 WP_162539088.1 histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-89)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12302.46 Da        Isoelectric Point: 10.7402

>T136001 WP_162539083.1 NZ_CP042596:c3924369-3924046 [Granulicella sp. WH15]
MGWVVGFLNEEVKASLDAFPLDIRASFQRISELIQSHGLERVREPYVKHLEGPLWEMRMKGRSGIARACYVTAVGKRVVV
VHVFEKKTQKTPRREILTALKRAKEVQ

Download         Length: 324 bp

>T136001 NZ_CP042596:c3924369-3924046 [Granulicella sp. WH15]
ATGGGATGGGTGGTTGGATTTTTGAATGAAGAGGTAAAGGCATCGCTCGATGCGTTCCCTTTGGACATTCGAGCGAGCTT
CCAACGCATATCCGAATTGATTCAGTCGCATGGTCTGGAGCGGGTGCGGGAACCCTATGTGAAACACCTGGAGGGTCCGC
TGTGGGAGATGCGTATGAAGGGCAGGAGCGGAATTGCGCGGGCCTGTTATGTCACTGCCGTGGGGAAGCGGGTCGTCGTC
GTTCATGTCTTTGAGAAGAAAACGCAGAAAACACCAAGGCGGGAGATTCTAACCGCCCTCAAACGGGCAAAGGAGGTTCA
ATGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11783.46 Da        Isoelectric Point: 8.5277

>AT136001 WP_162539082.1 NZ_CP042596:c3924049-3923732 [Granulicella sp. WH15]
MKRKFIPAEESFAQWKKDPKYVAEYAALEEEFALASALIEARGNADMTQEEVAEAMGTTQAVVARLESGKVLPSTRTLER
FAKATRTRLRISFEPNHEPVALKRG

Download         Length: 318 bp

>AT136001 NZ_CP042596:c3924049-3923732 [Granulicella sp. WH15]
ATGAAGCGTAAATTTATACCGGCTGAAGAGTCCTTCGCACAGTGGAAGAAAGATCCGAAGTACGTCGCTGAATATGCTGC
GTTAGAGGAGGAGTTTGCACTTGCGTCCGCATTGATCGAGGCCAGGGGAAATGCCGACATGACACAGGAAGAGGTTGCGG
AGGCGATGGGAACGACGCAGGCCGTCGTTGCGCGGCTTGAGAGCGGCAAAGTCTTGCCCTCTACGCGCACGCTGGAGCGC
TTTGCGAAAGCGACCCGCACTCGACTTCGTATCAGCTTTGAACCCAATCACGAGCCTGTTGCATTGAAGCGGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References