Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1811435..1811937 Replicon chromosome
Accession NZ_CP042585
Organism Escherichia coli strain LD91-1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FQR64_RS09185 Protein ID WP_000767829.1
Coordinates 1811683..1811937 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FQR64_RS09180 Protein ID WP_001259255.1
Coordinates 1811435..1811686 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQR64_RS09155 1806613..1807680 - 1068 WP_000080060.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
FQR64_RS09160 1807680..1808750 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
FQR64_RS09165 1808747..1810051 - 1305 WP_001317939.1 histidinol dehydrogenase -
FQR64_RS09170 1810057..1810956 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
FQR64_RS09175 1811102..1811152 - 51 WP_001364200.1 his operon leader peptide -
FQR64_RS09180 1811435..1811686 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FQR64_RS09185 1811683..1811937 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FQR64_RS09190 1812020..1812844 + 825 WP_000754763.1 SDR family oxidoreductase -
FQR64_RS09195 1812890..1813819 + 930 WP_000803351.1 LysR family transcriptional regulator -
FQR64_RS09200 1814034..1814096 + 63 WP_010723108.1 membrane protein YoeI -
FQR64_RS09205 1814086..1815444 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FQR64_RS09210 1815676..1816680 + 1005 WP_023277805.1 transport protein YeeE -
FQR64_RS09215 1816694..1816921 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T135953 WP_000767829.1 NZ_CP042585:1811683-1811937 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T135953 NZ_CP042585:1811683-1811937 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT135953 WP_001259255.1 NZ_CP042585:1811435-1811686 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT135953 NZ_CP042585:1811435-1811686 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References