Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 331101..331687 Replicon chromosome
Accession NZ_CP042520
Organism Klebsiella pneumoniae strain C2

Toxin (Protein)


Gene name doc Uniprot ID A0A331ME34
Locus tag FR744_RS01555 Protein ID WP_025861226.1
Coordinates 331319..331687 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag FR744_RS01550 Protein ID WP_004174006.1
Coordinates 331101..331322 (+) Length 74 a.a.

Genomic Context


FR744_RS01530FR744_RS01535FR744_RS01540FR744_RS01545FR744_RS01550FR744_RS01555FR744_RS01560FR744_RS01565FR744_RS01570FR744_RS01575
Location: 327257..328183 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Location: 328180..329457 (1278 bp)
Type: Others
Protein ID: WP_004174005.1
Location: 329454..330221 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 330223..330936 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 331101..331322 (222 bp)
Type: Antitoxin
Protein ID: WP_004174006.1
Location: 331319..331687 (369 bp)
Type: Toxin
Protein ID: WP_025861226.1
Location: 331960..333276 (1317 bp)
Type: Others
Protein ID: WP_004174008.1
Location: 333383..334270 (888 bp)
Type: Others
Protein ID: WP_014906831.1
Location: 334267..335112 (846 bp)
Type: Others
Protein ID: WP_004145129.1
Location: 335114..336184 (1071 bp)
Type: Others
Protein ID: WP_004150074.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FR744_RS01530327257..328183+927WP_002920807.1high-affinity branched-chain amino acid ABC transporter permease LivH-
FR744_RS01535328180..329457+1278WP_004174005.1branched chain amino acid ABC transporter permease LivM-
FR744_RS01540329454..330221+768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
FR744_RS01545330223..330936+714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
FR744_RS01550331101..331322+222WP_004174006.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
FR744_RS01555331319..331687+369WP_025861226.1type II toxin-antitoxin system death-on-curing family toxinToxin
FR744_RS01560331960..333276+1317WP_004174008.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
FR744_RS01565333383..334270+888WP_014906831.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
FR744_RS01570334267..335112+846WP_004145129.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
FR744_RS01575335114..336184+1071WP_004150074.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--329454..3369217467


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13551.98 Da        Isoelectric Point: 8.6410

>T135793 WP_025861226.1 NZ_CP042520:331319-331687 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGIKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T135793 NZ_CP042520:331319-331687 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT135793 WP_004174006.1 NZ_CP042520:331101-331322 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT135793 NZ_CP042520:331101-331322 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A331ME34


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E5YJY7

References