Detailed information of TA system TA135766

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4363583..4364235
• Replicon: chromosome
• Accession: NZ_CP042512
• Organism: Serratia marcescens strain E28

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FR888_RS21300
• Protein ID: WP_038878669.1
• Coordinates: 4363583..4363927 (+)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B4GZD7
• Locus tag: FR888_RS21305
• Protein ID: WP_038878665.1
• Coordinates: 4363933..4364235 (+)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR888_RS28635	4359739..4359924	-	186	WP_038878678.1	hypothetical protein	-
FR888_RS21290	4359925..4362183	-	2259	WP_038878674.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
FR888_RS21295	4362404..4363423	+	1020	WP_038878671.1	HTH-type transcriptional regulator GalR	-
FR888_RS21300	4363583..4363927	+	345	WP_038878669.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FR888_RS21305	4363933..4364235	+	303	WP_038878665.1	helix-turn-helix transcriptional regulator	Antitoxin
FR888_RS21310	4364263..4365525	-	1263	WP_038878662.1	diaminopimelate decarboxylase	-
FR888_RS21315	4365659..4366582	+	924	WP_060434145.1	LysR family transcriptional regulator	-
FR888_RS21320	4366610..4367518	-	909	WP_015378928.1	LysR family transcriptional regulator	-
FR888_RS21325	4367627..4368511	+	885	WP_033635778.1	MBL fold metallo-hydrolase	-
FR888_RS21330	4368580..4369227	+	648	WP_047729966.1	DsbA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13367.40 Da
• Isoelectric Point: 10.6629

>T135766 WP_038878669.1 NZ_CP042512:4363583-4363927 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDQRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T135766 NZ_CP042512:4363583-4363927 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAATTGGCACGGCCGCATGCCGATACGCTGCATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCATTCAACATCGCGGGCGCCCTTTCAGGGTATTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACCGGCGACCAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11111.04 Da
• Isoelectric Point: 10.3986

>AT135766 WP_038878665.1 NZ_CP042512:4363933-4364235 [Serratia marcescens]
MAKPLSQLIDKLDPAVVATARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT135766 NZ_CP042512:4363933-4364235 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCACTGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAACTGTCATCGCTCAAACGCTATATCGAGGCGATG
GGTGGCACGCTGTCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GZD7