Detailed information of TA system TA135735

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2893205..2893851
• Replicon: chromosome
• Accession: NZ_CP042499
• Organism: Enterobacter sp. E76

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FR762_RS13705
• Protein ID: WP_151604128.1
• Coordinates: 2893205..2893558 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FR762_RS13710
• Protein ID: WP_151604130.1
• Coordinates: 2893555..2893851 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-105)

Antitoxin

• HigA2-like, helix-turn-helix domain (8-88)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13612.66 Da
• Isoelectric Point: 9.2409

>T135735 WP_151604128.1 NZ_CP042499:2893205-2893558 [Enterobacter sp. E76]
MTWTVVFTPEFEQWLYDQELGLQDRVQASLVPLEAAGPALGRPMVDTLAGSRYPNMKELRVQYGGDPWRILFAFDYNREA
VMLYGGKKVGKKRFYTSLIARVDAIFERYLARRKDQE

Nucleotide

• Length: 354 bp

>T135735 NZ_CP042499:2893205-2893558 [Enterobacter sp. E76]
ATGACATGGACGGTTGTCTTTACGCCAGAGTTTGAACAATGGCTGTATGACCAGGAACTGGGATTACAGGATCGCGTGCA
AGCCTCTTTAGTCCCACTTGAAGCTGCCGGCCCAGCTTTGGGTCGCCCTATGGTTGATACGCTTGCCGGTTCACGTTATC
CCAATATGAAAGAGCTTCGCGTGCAGTATGGTGGTGATCCCTGGAGGATATTGTTTGCATTTGATTACAATCGAGAAGCG
GTAATGCTTTATGGCGGAAAGAAAGTAGGGAAAAAGCGCTTTTATACCTCGTTAATTGCGCGAGTTGATGCAATTTTTGA
ACGTTATCTTGCCCGTAGAAAGGATCAGGAATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10959.69 Da
• Isoelectric Point: 5.9126

>AT135735 WP_151604130.1 NZ_CP042499:2893555-2893851 [Enterobacter sp. E76]
MKTLQQHLAELSPERREKIMRMADEIAAENGLPTIREMRAMSQQELAERLGVTQPAVAAMERRGDDIKVSTLKRYAEALG
GELKISIELPEGSRVISL

Nucleotide

• Length: 297 bp

>AT135735 NZ_CP042499:2893555-2893851 [Enterobacter sp. E76]
ATGAAAACATTACAGCAACATCTCGCAGAACTTTCTCCTGAACGTCGTGAGAAAATTATGCGTATGGCGGATGAAATCGC
TGCCGAAAACGGCTTACCGACCATCAGAGAAATGCGCGCCATGTCGCAGCAGGAGCTTGCCGAAAGGCTGGGCGTAACCC
AGCCTGCGGTGGCCGCCATGGAGCGGCGCGGAGATGATATTAAAGTCTCGACGTTGAAACGTTACGCAGAAGCCCTGGGC
GGTGAATTGAAGATCAGCATCGAACTGCCCGAAGGAAGCAGAGTGATTTCACTCTGA