Detailed information of TA system TA135733

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 2361913..2362742
• Replicon: chromosome
• Accession: NZ_CP042499
• Organism: Enterobacter sp. E76

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: FR762_RS11310
• Protein ID: WP_151603749.1
• Coordinates: 2362260..2362742 (+)
• Length: 161 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: FR762_RS11305
• Protein ID: WP_125295554.1
• Coordinates: 2361913..2362257 (+)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR762_RS11280	2357141..2358049	+	909	WP_125295559.1	L(+)-tartrate dehydratase subunit alpha	-
FR762_RS11285	2358046..2358651	+	606	WP_125295558.1	L(+)-tartrate dehydratase subunit beta	-
FR762_RS11290	2358708..2360168	+	1461	WP_151603747.1	anion permease	-
FR762_RS11295	2360340..2360651	+	312	WP_125295556.1	acid resistance repetitive basic protein Asr	-
FR762_RS11300	2360782..2361759	-	978	WP_144130038.1	porphobilinogen synthase	-
FR762_RS11305	2361913..2362257	+	345	WP_125295554.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
FR762_RS11310	2362260..2362742	+	483	WP_151603749.1	type II toxin-antitoxin system YhaV family toxin	Toxin
FR762_RS11315	2362794..2363975	-	1182	WP_125295552.1	D-alanyl-D-alanine- carboxypeptidase/endopeptidase AmpH	-
FR762_RS11320	2364346..2365560	+	1215	WP_125295551.1	peptide antibiotic transporter SbmA	-
FR762_RS11325	2365579..2366664	+	1086	WP_144130042.1	DUF1615 domain-containing protein	-
FR762_RS11330	2366667..2366984	-	318	WP_125295549.1	DUF2755 family protein	-
FR762_RS11335	2367269..2367484	+	216	WP_125295548.1	DUF2754 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (12-147)

Antitoxin

• PrlF antitoxin (15-113)

Sequences

Toxin

Protein

• Length: 161 a.a.
• Molecular weight: 18498.27 Da
• Isoelectric Point: 10.1532

>T135733 WP_151603749.1 NZ_CP042499:2362260-2362742 [Enterobacter sp. E76]
MNGMRAVGPWKVYQHPCFVAQVKALRDEVAALKHHYPDDYRNKAATRLLAAINNARKDISADPTQAKFRLGDTLGAGYRH
WFRAKFLGQYRLFFRYSLRERIIILAWVNDSQTKRAYGNKRDAYKVFGEMLASGYPPDDWEALLKETMKQVSLSLCEPQP

Nucleotide

• Length: 483 bp

>T135733 NZ_CP042499:2362260-2362742 [Enterobacter sp. E76]
ATGAATGGAATGCGGGCAGTGGGCCCATGGAAAGTGTATCAACACCCCTGTTTTGTTGCCCAGGTTAAGGCGCTTCGGGA
CGAGGTAGCCGCGCTCAAACATCACTATCCTGACGACTACCGAAACAAAGCGGCAACCAGGCTGTTAGCGGCTATCAACA
ACGCCCGCAAAGATATCTCTGCTGACCCAACCCAGGCAAAATTTCGCCTGGGTGACACGTTGGGCGCGGGTTACAGGCAC
TGGTTTCGGGCAAAGTTTCTCGGCCAGTATCGCTTATTTTTTCGCTATAGCCTGAGAGAACGCATCATTATTCTCGCATG
GGTCAATGATTCGCAAACGAAGCGCGCTTATGGCAATAAGCGAGATGCGTATAAGGTTTTCGGTGAAATGCTGGCTTCAG
GGTATCCACCGGATGACTGGGAAGCCTTACTCAAAGAGACGATGAAGCAAGTCAGCCTGAGTCTGTGCGAACCTCAACCC
TGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12402.85 Da
• Isoelectric Point: 3.9590

>AT135733 WP_125295554.1 NZ_CP042499:2361913-2362257 [Enterobacter sp. E76]
MNNVVMAGVTLRASSKLTARSQTTIPASVRDAMNLKPGEEIEYAVLADGQVLMTRKQTDAEDDPVMEGFLSFLANDIQHN
PSQIHALDTAFWDDVEALTEGVDVDLDAPLADEK

Nucleotide

• Length: 345 bp

>AT135733 NZ_CP042499:2361913-2362257 [Enterobacter sp. E76]
ATGAATAACGTAGTCATGGCAGGCGTAACGCTGCGAGCTTCCTCGAAATTAACTGCCCGTAGCCAGACAACCATTCCGGC
TTCTGTTAGAGATGCTATGAATTTAAAACCTGGCGAAGAGATTGAATATGCCGTCCTGGCTGACGGGCAGGTGCTGATGA
CGCGAAAGCAAACGGATGCCGAAGACGATCCGGTTATGGAAGGTTTTCTGAGCTTCCTTGCTAACGATATTCAGCACAAT
CCGTCGCAGATCCACGCGCTGGATACGGCGTTCTGGGATGACGTAGAGGCATTAACAGAAGGTGTGGATGTCGATCTCGA
TGCGCCGCTTGCTGATGAGAAATGA