Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 931584..932929 Replicon chromosome
Accession NZ_CP042499
Organism Enterobacter sp. E76

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag FR762_RS04405 Protein ID WP_151602789.1
Coordinates 931584..932618 (-) Length 345 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag FR762_RS04410 Protein ID WP_125292711.1
Coordinates 932618..932929 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FR762_RS04375 927908..929236 + 1329 WP_125292705.1 poly-beta-1,6 N-acetyl-D-glucosamine synthase -
FR762_RS04380 929239..929739 + 501 WP_151605597.1 poly-beta-1,6-N-acetyl-D-glucosamine biosynthesis protein PgaD -
FR762_RS04385 929784..930323 - 540 WP_151602783.1 GNAT family N-acetyltransferase -
FR762_RS04390 930302..930592 - 291 WP_151602785.1 DUF1778 domain-containing protein -
FR762_RS04395 930674..931204 - 531 WP_151602787.1 hypothetical protein -
FR762_RS04400 931340..931531 + 192 WP_144131794.1 toxin-antitoxin system HicB family antitoxin -
FR762_RS04405 931584..932618 - 1035 WP_151602789.1 HipA domain-containing protein Toxin
FR762_RS04410 932618..932929 - 312 WP_125292711.1 HipA N-terminal domain-containing protein Antitoxin
FR762_RS04415 932914..933237 - 324 WP_151602791.1 helix-turn-helix domain-containing protein -
FR762_RS04420 933435..934445 - 1011 WP_125292713.1 dipeptide ABC transporter ATP-binding subunit DppF -
FR762_RS04425 934432..935424 - 993 WP_151602793.1 dipeptide ABC transporter ATP-binding protein -
FR762_RS04430 935436..936338 - 903 WP_125292716.1 dipeptide ABC transporter permease DppC -
FR762_RS04435 936348..937367 - 1020 WP_125292718.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-306)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 345 a.a.        Molecular weight: 38514.16 Da        Isoelectric Point: 6.7692

>T135729 WP_151602789.1 NZ_CP042499:c932618-931584 [Enterobacter sp. E76]
MANCRISLTPLHPRDEATGYSSRALKQLTGNGRADPQLPFSRSEFIAELPKAQAGMSISGYQPKLQVVQQNGAFNVVDHQ
GDYILKPSPAEFPFLAENEHATMTLMSRLGFAVPPHGLVRFANTQPGDADEYAFIVRRFDRDARGKALHQEQLDAAMNVG
EKYGKIREDGKRYVSYQQLAEFLLAHVNDNLAFKIDLFRRIAYAYLLGNNDMHLRNFGLILPVAGAPELAPVYDFISVAP
YPAAFNSGFLALPLLRCEEGEQDLAPGMKTQYGEYLGKDFLLLGEAMGLARAVVLRLFAQMQKEAVTVEKVYRASFMPES
DVARVLECYRHRLHRIMNVDVVEL

Download         Length: 1035 bp

>T135729 NZ_CP042499:c932618-931584 [Enterobacter sp. E76]
ATGGCAAACTGTCGAATCTCTCTGACGCCGCTGCATCCGCGCGATGAGGCGACGGGTTACTCCTCGCGCGCTTTAAAACA
GCTCACCGGCAATGGACGGGCCGATCCGCAGCTTCCTTTCTCCCGCAGCGAGTTTATTGCTGAACTGCCGAAAGCGCAGG
CGGGGATGAGTATTTCCGGCTATCAGCCCAAATTACAGGTAGTGCAGCAAAACGGCGCGTTTAACGTGGTTGATCATCAG
GGCGACTATATTCTTAAACCCTCTCCGGCGGAGTTTCCTTTCCTGGCGGAAAACGAACACGCCACCATGACGTTGATGTC
GCGTCTGGGGTTTGCCGTGCCGCCGCACGGGTTGGTACGTTTTGCTAACACCCAGCCTGGCGATGCGGATGAATATGCCT
TTATCGTGCGCCGCTTCGACCGGGACGCCCGGGGAAAAGCGTTGCATCAGGAGCAACTGGACGCCGCGATGAACGTGGGC
GAAAAGTACGGCAAAATTCGCGAAGACGGTAAACGGTATGTGAGTTATCAACAGCTGGCTGAGTTCCTGCTTGCTCACGT
TAATGATAACCTGGCGTTCAAAATCGACCTGTTCCGGCGCATTGCTTACGCTTACCTGCTGGGCAACAACGATATGCACT
TGCGTAATTTCGGGCTGATCCTGCCGGTTGCGGGCGCGCCTGAACTGGCACCGGTTTATGATTTTATCAGCGTTGCGCCT
TATCCGGCCGCGTTTAACAGCGGGTTTTTAGCACTGCCGCTTCTGCGCTGCGAAGAAGGGGAACAGGATCTGGCCCCGGG
CATGAAAACCCAGTACGGCGAATATCTCGGCAAAGATTTTTTACTGCTGGGCGAGGCGATGGGGCTGGCGCGTGCCGTGG
TGTTACGCCTGTTTGCACAGATGCAGAAAGAGGCGGTGACGGTTGAGAAGGTTTATCGCGCGTCATTTATGCCTGAAAGC
GATGTGGCGCGGGTATTAGAGTGCTATCGGCACCGGCTCCATCGGATAATGAATGTGGATGTGGTGGAGCTGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11804.45 Da        Isoelectric Point: 6.7163

>AT135729 WP_125292711.1 NZ_CP042499:c932929-932618 [Enterobacter sp. E76]
MHRRVTVLLYGEPVGELVQEATGFRFTYRDDYQGPPLSLSLPVSQRTFHCTTLHPFFVSLAPEGWLRNRYSQLQQRDEKD
LLGMLIDNGKNLIGAVQIRAEEA

Download         Length: 312 bp

>AT135729 NZ_CP042499:c932929-932618 [Enterobacter sp. E76]
ATGCACCGCCGTGTAACCGTGCTGCTGTATGGCGAACCGGTTGGCGAACTGGTGCAGGAGGCAACTGGTTTTCGCTTTAC
CTATCGCGATGACTATCAGGGGCCGCCACTGTCGCTGAGTTTACCGGTCAGTCAGCGCACATTTCACTGCACCACGCTGC
ACCCTTTTTTTGTCTCACTGGCTCCGGAAGGCTGGCTCAGGAATCGCTATAGCCAGCTTCAACAGCGGGATGAAAAAGAT
CTGCTGGGAATGCTTATTGATAACGGTAAAAACCTGATTGGCGCGGTGCAAATCAGGGCTGAGGAGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References