Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1261872..1262482 Replicon chromosome
Accession NZ_CP042467
Organism Microvenator marinus strain V1718

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FRD01_RS05355 Protein ID WP_146958328.1
Coordinates 1261872..1262162 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FRD01_RS05360 Protein ID WP_146958330.1
Coordinates 1262174..1262482 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRD01_RS05330 (FRD01_05330) 1257297..1258067 + 771 WP_146958318.1 MYXO-CTERM sorting domain-containing protein -
FRD01_RS05335 (FRD01_05335) 1258119..1259246 + 1128 WP_146958320.1 hypothetical protein -
FRD01_RS05340 (FRD01_05340) 1259324..1260652 + 1329 WP_146958322.1 APC family permease -
FRD01_RS05345 (FRD01_05345) 1260642..1261037 + 396 WP_146958324.1 hypothetical protein -
FRD01_RS05350 (FRD01_05350) 1261044..1261817 + 774 WP_146958326.1 hypothetical protein -
FRD01_RS05355 (FRD01_05355) 1261872..1262162 + 291 WP_146958328.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FRD01_RS05360 (FRD01_05360) 1262174..1262482 + 309 WP_146958330.1 HigA family addiction module antitoxin Antitoxin
FRD01_RS05365 (FRD01_05365) 1262485..1263633 + 1149 WP_146958332.1 AAA family ATPase -
FRD01_RS05370 (FRD01_05370) 1263640..1267131 + 3492 WP_146958334.1 DUF5682 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-96)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-88)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10937.40 Da        Isoelectric Point: 5.7035

>T135661 WP_146958328.1 NZ_CP042467:1261872-1262162 [Microvenator marinus]
MIVSFDDGTAEEFFNTGKIPRKHCRWMNVSRIVARKLDMLNAAAELSDLRSPPGNQLEALKGSLDGKFSIRVNDQWRIVF
GWTDDGPEEVKVVDYH

Download         Length: 291 bp

>T135661 NZ_CP042467:1261872-1262162 [Microvenator marinus]
ATGATAGTTTCCTTTGATGATGGTACCGCCGAGGAGTTTTTCAACACTGGAAAAATTCCCCGGAAACACTGCCGCTGGAT
GAACGTTAGCAGGATCGTAGCGCGAAAGCTCGACATGCTGAACGCTGCAGCGGAGCTAAGCGATTTGCGAAGTCCTCCTG
GAAACCAACTTGAAGCACTCAAAGGCTCCTTGGATGGCAAGTTTAGCATACGAGTCAACGACCAGTGGCGGATTGTCTTC
GGGTGGACCGATGATGGACCGGAAGAAGTGAAAGTGGTGGACTACCACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11401.23 Da        Isoelectric Point: 7.2017

>AT135661 WP_146958330.1 NZ_CP042467:1262174-1262482 [Microvenator marinus]
MRRTIKRKPTTPGEMLSEEFLIPAELTQSEFALHLGVDVKTINRLINGRTRLTPALAYKIAAALNTTPDFWMNLQMAVDL
YDVSADSAPLPLPLPQFQHPQG

Download         Length: 309 bp

>AT135661 NZ_CP042467:1262174-1262482 [Microvenator marinus]
ATGAGACGAACTATAAAGCGAAAGCCCACGACACCTGGCGAGATGCTATCCGAAGAATTCTTGATTCCCGCAGAACTCAC
GCAATCGGAATTTGCTCTGCATCTCGGAGTCGATGTCAAAACTATCAACCGATTGATAAACGGGCGAACACGATTGACGC
CTGCCTTGGCATACAAAATCGCGGCAGCACTCAATACCACGCCGGACTTTTGGATGAATCTTCAAATGGCTGTAGACCTT
TACGATGTATCGGCCGATTCAGCACCACTCCCTCTTCCACTACCGCAATTCCAACATCCTCAAGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References