135659

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 245375..245964 Replicon chromosome
Accession NZ_CP042466
Organism Geobacter sp. FeAm09

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FO488_RS01130 Protein ID WP_149208842.1
Coordinates 245375..245653 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FO488_RS01135 Protein ID WP_205743395.1
Coordinates 245662..245964 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO488_RS01110 241182..241934 + 753 WP_149208838.1 HAMP domain-containing histidine kinase -
FO488_RS01115 241972..242868 - 897 WP_149208839.1 DnaJ domain-containing protein -
FO488_RS01120 243134..244996 + 1863 WP_149208840.1 metallophosphoesterase -
FO488_RS01125 245015..245185 + 171 WP_149208841.1 twin-arginine translocase TatA/TatE family subunit -
FO488_RS01130 245375..245653 + 279 WP_149208842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FO488_RS01135 245662..245964 + 303 WP_205743395.1 HigA family addiction module antidote protein Antitoxin
FO488_RS01140 246660..247844 - 1185 WP_149208844.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
FO488_RS01145 248306..248734 + 429 WP_149208845.1 MarR family transcriptional regulator -
FO488_RS01150 248772..250178 + 1407 WP_149208846.1 protoporphyrinogen oxidase -
FO488_RS01155 250259..250891 - 633 WP_149208847.1 cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10982.43 Da        Isoelectric Point: 7.7493

>T135659 WP_149208842.1 NZ_CP042466:245375-245653 [Geobacter sp. FeAm09]
MIRSFACKQTEKFYHGERVPRFQAFAQQAEKRLQILESATCVEDLMNLPSNRFEALGGDRKGRQSIRINQQWRICFEWRE
DGPYNVEIVDYH

Download         Length: 279 bp

>T135659 NZ_CP042466:245375-245653 [Geobacter sp. FeAm09]
ATGATCCGGTCATTCGCCTGCAAGCAAACTGAAAAGTTCTATCACGGCGAACGCGTCCCGCGTTTTCAGGCTTTTGCCCA
ACAGGCTGAAAAAAGACTGCAAATTCTCGAAAGCGCCACCTGCGTGGAAGATTTGATGAACCTGCCAAGCAACCGCTTCG
AGGCTTTGGGTGGCGACCGGAAGGGCCGGCAAAGCATACGCATCAACCAGCAATGGCGGATCTGCTTCGAGTGGCGGGAG
GATGGCCCGTACAACGTGGAGATTGTCGATTATCATTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11095.81 Da        Isoelectric Point: 7.3177

>AT135659 WP_205743395.1 NZ_CP042466:245662-245964 [Geobacter sp. FeAm09]
IFMNAMRPIHPGEILKDELAEIDMTANAFAHALHVPANRITAILNGTRSITADTALRISRYFGTTPEFWLNLQTAYDLKV
ARQTVGDKIELSVTPMKQAA

Download         Length: 303 bp

>AT135659 NZ_CP042466:245662-245964 [Geobacter sp. FeAm09]
ATCTTTATGAATGCCATGCGCCCCATACACCCCGGCGAAATCCTGAAGGATGAACTTGCCGAGATCGACATGACGGCCAA
CGCCTTTGCGCACGCCCTGCATGTGCCCGCAAACCGGATTACGGCCATCCTGAACGGCACCCGTTCCATCACTGCCGACA
CCGCGCTGCGCATCTCCCGTTATTTCGGCACGACGCCGGAATTTTGGCTGAACCTCCAGACGGCATACGACCTGAAGGTT
GCCCGGCAGACCGTTGGCGACAAGATTGAGCTGAGTGTAACCCCGATGAAGCAGGCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References