Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 43798..44389 Replicon chromosome
Accession NZ_CP042466
Organism Geobacter sp. FeAm09

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FO488_RS00265 Protein ID WP_149208685.1
Coordinates 43798..44076 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FO488_RS00270 Protein ID WP_149208686.1
Coordinates 44093..44389 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FO488_RS00240 40084..40980 + 897 WP_149208682.1 hypothetical protein -
FO488_RS00245 40985..41461 + 477 WP_205743392.1 transposase -
FO488_RS00250 41554..42074 + 521 Protein_51 phospholipase D family protein -
FO488_RS00255 42435..42629 + 195 WP_149208683.1 DUF3775 domain-containing protein -
FO488_RS00260 42761..43693 + 933 WP_149208684.1 hypothetical protein -
FO488_RS00265 43798..44076 + 279 WP_149208685.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FO488_RS00270 44093..44389 + 297 WP_149208686.1 HigA family addiction module antidote protein Antitoxin
FO488_RS00275 44507..45202 + 696 WP_149208687.1 hypothetical protein -
FO488_RS00280 45642..49109 - 3468 WP_149208688.1 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1160..166139 164979


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10951.37 Da        Isoelectric Point: 6.4513

>T135658 WP_149208685.1 NZ_CP042466:43798-44076 [Geobacter sp. FeAm09]
MIRSFACKHTEKIYNGERIPRFQAFAQQAEKRLQILDSATCIEDLMNLPSNRFEALSGDRKGQQSIRINQQWRLCFEWRE
DGPYDVEIVDYH

Download         Length: 279 bp

>T135658 NZ_CP042466:43798-44076 [Geobacter sp. FeAm09]
ATGATTCGTTCATTCGCGTGCAAGCATACCGAAAAAATATACAACGGTGAACGGATACCGCGTTTTCAGGCTTTTGCCCA
ACAGGCTGAGAAAAGGCTCCAAATACTTGACAGTGCCACCTGCATTGAAGACTTGATGAATCTTCCGAGTAATCGTTTCG
AGGCATTGAGTGGAGATCGAAAGGGGCAGCAGAGCATTCGGATTAATCAGCAGTGGCGCTTATGCTTCGAGTGGCGCGAG
GATGGACCGTACGACGTCGAAATTGTTGATTACCACTGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10890.65 Da        Isoelectric Point: 6.9788

>AT135658 WP_149208686.1 NZ_CP042466:44093-44389 [Geobacter sp. FeAm09]
MNAMRPIHPGEVLKDELIEIGMSANVFARLLCVPTNRITAILNGERSVTADTALRLSRFFGTTPEFWLNLQTAYDLKVAK
QTSGEKIELDITPMKQAA

Download         Length: 297 bp

>AT135658 NZ_CP042466:44093-44389 [Geobacter sp. FeAm09]
ATGAATGCTATGCGCCCCATACACCCCGGGGAGGTTCTGAAAGACGAGCTTATCGAGATCGGGATGAGCGCCAATGTTTT
TGCAAGATTATTGTGTGTGCCCACCAACCGGATCACGGCCATACTGAATGGCGAACGGTCTGTCACTGCCGACACAGCGC
TTCGGCTCTCTCGATTTTTCGGGACGACCCCTGAATTCTGGCTGAACCTCCAGACTGCTTACGATCTTAAGGTTGCGAAG
CAGACATCTGGTGAAAAGATTGAACTTGATATTACCCCAATGAAACAGGCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References