Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 887394..888025 Replicon chromosome
Accession NZ_CP042382
Organism Pistricoccus aurantiacus strain CBA4606

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FGL86_RS04240 Protein ID WP_147183427.1
Coordinates 887394..887687 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FGL86_RS04245 Protein ID WP_147183428.1
Coordinates 887702..888025 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL86_RS04220 883550..884152 + 603 WP_147183423.1 RdgB/HAM1 family non-canonical purine NTP pyrophosphatase -
FGL86_RS04225 884149..885318 + 1170 WP_147183424.1 radical SAM family heme chaperone HemW -
FGL86_RS04230 885430..886113 + 684 WP_147183425.1 OmpA family protein -
FGL86_RS04235 886192..887040 + 849 WP_147183426.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
FGL86_RS04240 887394..887687 + 294 WP_147183427.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FGL86_RS04245 887702..888025 + 324 WP_147183428.1 HigA family addiction module antidote protein Antitoxin
FGL86_RS04250 888226..889590 - 1365 WP_147183429.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
FGL86_RS04255 889681..891384 - 1704 WP_147183430.1 membrane protein insertase YidC -
FGL86_RS04260 891498..891875 - 378 WP_147183431.1 ribonuclease P protein component -
FGL86_RS04265 891889..892023 - 135 WP_147183432.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-70)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11414.85 Da        Isoelectric Point: 6.2186

>T135639 WP_147183427.1 NZ_CP042382:887394-887687 [Pistricoccus aurantiacus]
MAVEFRDAWLDAFYEQDQSHKKVPSTIEGALFRKIQILDAATQESDLRIPPGNRFEHLQGNLWGWCSIRVNKQYRLIFRW
EDSTALDTYLDPHAYKG

Download         Length: 294 bp

>T135639 NZ_CP042382:887394-887687 [Pistricoccus aurantiacus]
ATGGCGGTTGAGTTCAGGGATGCGTGGCTGGATGCTTTCTATGAGCAAGACCAGAGCCATAAGAAAGTACCCAGCACCAT
TGAAGGTGCCCTTTTCAGGAAGATTCAGATTCTCGATGCCGCGACGCAGGAGTCAGACTTAAGGATTCCGCCGGGTAACC
GGTTTGAACATTTGCAGGGAAACCTGTGGGGCTGGTGTTCCATCCGGGTAAACAAACAGTATCGCCTGATCTTTCGCTGG
GAAGACAGCACCGCCCTGGATACGTACCTGGACCCGCACGCGTACAAGGGTTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12190.21 Da        Isoelectric Point: 9.8626

>AT135639 WP_147183428.1 NZ_CP042382:887702-888025 [Pistricoccus aurantiacus]
MRTTKRRPVTVGQMLVTEFLEPMNIEISELAEAMGVHRNTLSRIVHDKGTLTAPMAIKLAAALGNTPEFWLNIQHAVELW
DVRHRAYEQEAKNVKRVKPHVLPLEQA

Download         Length: 324 bp

>AT135639 NZ_CP042382:887702-888025 [Pistricoccus aurantiacus]
ATGAGAACTACAAAGCGTCGTCCGGTGACCGTGGGCCAAATGCTGGTCACCGAGTTCCTGGAGCCGATGAATATTGAAAT
CAGTGAGCTGGCTGAAGCCATGGGTGTGCACAGAAATACCCTCAGTCGGATTGTTCATGACAAAGGCACCTTGACCGCGC
CCATGGCCATCAAGCTGGCAGCGGCTCTGGGAAATACACCGGAGTTCTGGCTGAACATTCAGCACGCGGTTGAGTTATGG
GATGTTCGTCATCGTGCCTATGAACAAGAAGCCAAGAATGTGAAGCGCGTTAAGCCCCACGTCCTGCCTCTGGAGCAAGC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References