Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1179081..1179597 Replicon chromosome
Accession NZ_CP042371
Organism Secundilactobacillus malefermentans strain CBA3618

Toxin (Protein)


Gene name yafQ Uniprot ID A0A4R5NS52
Locus tag FGL90_RS05640 Protein ID WP_010620350.1
Coordinates 1179081..1179362 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A4R5NSF0
Locus tag FGL90_RS05645 Protein ID WP_010620349.1
Coordinates 1179355..1179597 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGL90_RS05625 1175138..1176814 + 1677 WP_010620353.1 peptide ABC transporter substrate-binding protein -
FGL90_RS05630 1177084..1178439 - 1356 WP_187240459.1 NAD(P)/FAD-dependent oxidoreductase -
FGL90_RS05635 1178497..1178943 - 447 WP_010620351.1 MarR family transcriptional regulator -
FGL90_RS05640 1179081..1179362 - 282 WP_010620350.1 type II toxin-antitoxin system YafQ family toxin Toxin
FGL90_RS05645 1179355..1179597 - 243 WP_010620349.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FGL90_RS05650 1179737..1181107 - 1371 WP_147657259.1 FAD-dependent oxidoreductase -
FGL90_RS05655 1181194..1181808 - 615 WP_010620347.1 CadD family cadmium resistance transporter -
FGL90_RS05660 1181811..1182200 - 390 WP_147657261.1 hypothetical protein -
FGL90_RS05665 1182331..1182864 + 534 WP_010620345.1 N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-73)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11163.95 Da        Isoelectric Point: 8.0825

>T135631 WP_010620350.1 NZ_CP042371:c1179362-1179081 [Secundilactobacillus malefermentans]
MNEIKFKVAFQHEFKKHLKKIIKSGQYNIADFDLVYELLIRDIPLPARYNDHPLINRKPERECHIKPDWLLIYKFDADFV
KFIDTGSHSSLFD

Download         Length: 282 bp

>T135631 NZ_CP042371:c1179362-1179081 [Secundilactobacillus malefermentans]
ATGAATGAAATTAAGTTTAAAGTCGCTTTCCAGCATGAATTCAAAAAACATCTAAAAAAAATAATCAAAAGTGGTCAATA
CAACATTGCTGATTTTGATCTTGTTTATGAGCTGCTAATCAGAGACATCCCTTTACCAGCTCGTTATAACGATCATCCTT
TAATAAATAGAAAGCCTGAACGAGAATGCCATATTAAACCAGACTGGCTTCTCATTTATAAGTTTGATGCCGATTTCGTC
AAATTTATTGATACTGGGTCACATTCAAGTTTATTTGATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9026.21 Da        Isoelectric Point: 6.2142

>AT135631 WP_010620349.1 NZ_CP042371:c1179597-1179355 [Secundilactobacillus malefermentans]
MSTQIHFRMDETEKNKFETILNQLGLTPAQAFKIFAKKTIEAGGIPFEVSQPSNQLTAAINSHDYKEFTSAAEGLKWLHE

Download         Length: 243 bp

>AT135631 NZ_CP042371:c1179597-1179355 [Secundilactobacillus malefermentans]
ATGAGTACACAAATACATTTTCGTATGGATGAAACTGAGAAAAATAAGTTTGAAACTATCTTGAACCAATTAGGTTTAAC
CCCGGCCCAGGCGTTCAAAATCTTTGCAAAAAAGACCATTGAGGCAGGAGGTATTCCGTTTGAAGTCTCACAACCGAGCA
ATCAATTAACGGCCGCCATTAATAGCCACGACTACAAAGAATTTACTTCTGCCGCGGAAGGCCTGAAGTGGTTGCATGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R5NS52

Antitoxin

Source ID Structure
AlphaFold DB A0A4R5NSF0

References