Detailed information of TA system TA135629

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 21526..22129
• Replicon: plasmid pC54_002
• Accession: NZ_CP042366
• Organism: Acinetobacter pittii strain C54

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FR838_RS20400
• Protein ID: WP_000288004.1
• Coordinates: 21526..21855 (+)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FR838_RS20405
• Protein ID: WP_001258993.1
• Coordinates: 21842..22129 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FR838_RS20365	17898..18410	-	513	WP_000464612.1	Fic family protein	-
FR838_RS20370	18413..18598	-	186	WP_000755724.1	hypothetical protein	-
FR838_RS20375	18765..19697	+	933	WP_000743263.1	IS5 family transposase	-
FR838_RS20380	19828..20025	-	198	WP_025464206.1	hypothetical protein	-
FR838_RS20385	20118..20336	-	219	WP_000994925.1	hypothetical protein	-
FR838_RS20390	20393..20995	-	603	WP_000096286.1	hypothetical protein	-
FR838_RS20395	21202..21471	+	270	WP_000453245.1	transcriptional regulator	-
FR838_RS20400	21526..21855	+	330	WP_000288004.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FR838_RS20405	21842..22129	+	288	WP_001258993.1	helix-turn-helix domain-containing protein	Antitoxin
FR838_RS20410	22166..22354	-	189	WP_000340067.1	hypothetical protein	-
FR838_RS20415	22763..23086	-	324	Protein_33	DUF4236 domain-containing protein	-
FR838_RS20420	23095..23271	-	177	WP_002120129.1	hypothetical protein	-
FR838_RS21020	23343..23666	-	324	WP_005804845.1	hypothetical protein	-
FR838_RS20430	24021..24530	-	510	Protein_36	terminase	-
FR838_RS20435	24514..25037	-	524	Protein_37	DUF2280 domain-containing protein	-
FR838_RS20440	25128..25769	-	642	WP_000372120.1	hypothetical protein	-
FR838_RS20445	25738..26199	-	462	WP_000378528.1	hypothetical protein	-
FR838_RS20450	26260..26715	-	456	WP_001136766.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..76008	76008
	-	flank	IS/Tn	-	-	18765..19697	932

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12571.69 Da
• Isoelectric Point: 8.8102

>T135629 WP_000288004.1 NZ_CP042366:21526-21855 [Acinetobacter pittii]
MYTIEYYSEDVQDEILTLPDGLLARYFNLTDRMVIYGANLGEPHTLPMSKGLFELRLKSQEGIARVMYCTLVGKRIVMLH
SFVKKTQKTPKQDLNLALDRMKEVKNANT

Nucleotide

• Length: 330 bp

>T135629 NZ_CP042366:21526-21855 [Acinetobacter pittii]
ATGTATACAATTGAATATTACAGCGAAGACGTTCAGGATGAGATTCTTACATTACCTGATGGTCTTTTGGCTCGATATTT
TAACTTAACTGACCGTATGGTGATTTACGGCGCAAACTTAGGAGAACCTCACACATTACCAATGAGTAAAGGACTATTTG
AGTTGCGCTTAAAATCTCAAGAAGGTATTGCTCGTGTTATGTATTGCACACTAGTCGGTAAACGCATTGTAATGCTCCAT
AGTTTTGTTAAGAAAACCCAAAAAACACCTAAGCAAGATCTAAACCTAGCACTTGACCGCATGAAAGAGGTGAAAAATGC
GAACACATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10565.30 Da
• Isoelectric Point: 10.1453

>AT135629 WP_001258993.1 NZ_CP042366:21842-22129 [Acinetobacter pittii]
MRTHEEMKALALSRSAVRTEYERIEREEMPLLDMVLTARRDAGLSQAQIAERMGTSVPAVSRLEKALITGKPSPSIATLQ
KYAAAIGKHVEVRFV

Nucleotide

• Length: 288 bp

>AT135629 NZ_CP042366:21842-22129 [Acinetobacter pittii]
ATGCGAACACATGAAGAAATGAAAGCACTTGCATTATCTCGTTCAGCAGTGCGTACCGAATACGAACGAATTGAACGTGA
AGAAATGCCCCTGCTCGATATGGTACTTACTGCACGTCGAGATGCAGGTCTATCCCAAGCGCAAATCGCGGAACGCATGG
GAACAAGTGTACCTGCCGTTTCACGGCTAGAAAAAGCATTGATCACAGGCAAACCATCACCATCTATTGCCACATTGCAA
AAATATGCTGCGGCAATTGGTAAACATGTTGAAGTGCGTTTTGTCTAA