Detailed information of TA system TA135605

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 26078..26348
• Replicon: plasmid unnamed
• Accession: NZ_CP042362
• Organism: Lelliottia amnigena strain A167

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: FS593_RS21725
• Protein ID: WP_223176086.1
• Coordinates: 26232..26348 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	26078..26137 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FS593_RS21695	21861..22433	+	573	WP_235135836.1	hypothetical protein	-
FS593_RS21700	22503..24515	+	2013	WP_235135837.1	ParB/RepB/Spo0J family partition protein	-
FS593_RS21705	24552..24986	+	435	WP_235135838.1	conjugation system SOS inhibitor PsiB	-
FS593_RS21710	24983..25714	+	732	WP_235135839.1	plasmid SOS inhibition protein A	-
FS593_RS21715	25711..25941	+	231	WP_235135840.1	hypothetical protein	-
-	26016..26137	+	122	NuclAT_0	-	-
-	26016..26137	+	122	NuclAT_0	-	-
-	26016..26137	+	122	NuclAT_0	-	-
-	26016..26137	+	122	NuclAT_0	-	-
-	26078..26137	+	60	-	-	Antitoxin
FS593_RS21720	26132..26281	+	150	Protein_28	DUF5431 family protein	-
FS593_RS21725	26232..26348	+	117	WP_223176086.1	type I toxin-antitoxin system Hok family toxin	Toxin
FS593_RS21730	27324..27638	+	315	WP_235135841.1	hypothetical protein	-
FS593_RS21735	27644..28465	+	822	WP_235135842.1	DUF932 domain-containing protein	-
FS593_RS21740	28493..29032	-	540	WP_235135843.1	lytic transglycosylase domain-containing protein	-
FS593_RS21745	29687..30073	+	387	WP_235135844.1	relaxosome protein TraM	-
FS593_RS21750	30113..30754	-	642	WP_235135845.1	Arc family DNA-binding protein	-
FS593_RS21755	30951..31304	+	354	WP_235135846.1	type IV conjugative transfer system pilin TraA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..141490	141490

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-34)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4490.28 Da
• Isoelectric Point: 8.5046

>T135605 WP_223176086.1 NZ_CP042362:26232-26348 [Lelliottia amnigena]
VCLTLLIFTYLTRKSLCEIRYRDTNREVAAFMAYESAK

Nucleotide

• Length: 117 bp

>T135605 NZ_CP042362:26232-26348 [Lelliottia amnigena]
GTGTGTCTCACACTGCTGATATTCACTTACCTGACGCGCAAATCGCTCTGCGAAATTCGTTACAGGGACACGAACAGGGA
GGTGGCCGCTTTTATGGCTTACGAATCCGCTAAGTAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT135605 NZ_CP042362:26078-26137 [Lelliottia amnigena]
AGCAGAAAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCCACCTGTATGTCT

Structures

Antitoxin