Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 18901..19600 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP042359 | ||
| Organism | Rahnella aquatilis strain H145 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | - |
| Locus tag | FS594_RS26110 | Protein ID | WP_217137596.1 |
| Coordinates | 18901..19197 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | - |
| Locus tag | FS594_RS26115 | Protein ID | WP_217137595.1 |
| Coordinates | 19199..19600 (+) | Length | 134 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FS594_RS26070 (FS594_26245) | 14057..14896 | + | 840 | WP_235174826.1 | VOC family protein | - |
| FS594_RS26075 (FS594_26255) | 15475..15657 | + | 183 | Protein_16 | DUF905 family protein | - |
| FS594_RS26080 (FS594_26260) | 15999..16241 | + | 243 | WP_235174827.1 | hypothetical protein | - |
| FS594_RS26085 (FS594_26265) | 16511..16852 | + | 342 | WP_235174829.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FS594_RS26090 (FS594_26270) | 16849..17163 | + | 315 | WP_235174831.1 | type II toxin-antitoxin system MqsA family antitoxin | - |
| FS594_RS26095 (FS594_26280) | 17641..17880 | + | 240 | Protein_20 | LysR family transcriptional regulator | - |
| FS594_RS26100 (FS594_26285) | 17877..18125 | + | 249 | WP_217137598.1 | EexN family lipoprotein | - |
| FS594_RS26105 (FS594_26290) | 18261..18806 | + | 546 | WP_235174833.1 | hypothetical protein | - |
| FS594_RS26110 (FS594_26295) | 18901..19197 | + | 297 | WP_217137596.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| FS594_RS26115 (FS594_26300) | 19199..19600 | + | 402 | WP_217137595.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| FS594_RS26120 (FS594_26305) | 20287..20661 | + | 375 | WP_235174835.1 | hypothetical protein | - |
| FS594_RS26125 (FS594_26310) | 20671..20898 | + | 228 | WP_112198754.1 | hypothetical protein | - |
| FS594_RS26130 (FS594_26315) | 20945..21274 | + | 330 | WP_235174837.1 | hypothetical protein | - |
| FS594_RS26135 (FS594_26320) | 21389..21634 | + | 246 | WP_235174839.1 | hypothetical protein | - |
| FS594_RS26140 (FS594_26325) | 21688..22062 | + | 375 | WP_235174841.1 | DUF3085 domain-containing protein | - |
| FS594_RS26145 (FS594_26330) | 22056..22916 | + | 861 | WP_235174842.1 | DUF4942 domain-containing protein | - |
| FS594_RS26150 (FS594_26335) | 23106..23348 | - | 243 | WP_235174843.1 | hypothetical protein | - |
| FS594_RS26155 (FS594_26340) | 23631..23870 | + | 240 | WP_235174844.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | mrkH / mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA | 1..467533 | 467533 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 10763.42 Da Isoelectric Point: 8.5042
>T135587 WP_217137596.1 NZ_CP042359:18901-19197 [Rahnella aquatilis]
MEKRTPHTRLHIVQGLVAAGKVKATNTALNGADNLGLTFDDMCSAILGLTAADFFKSMTTYNDHTVWQDVYRPKLSCGDV
YLKLTVSNGVLIVSFKEK
MEKRTPHTRLHIVQGLVAAGKVKATNTALNGADNLGLTFDDMCSAILGLTAADFFKSMTTYNDHTVWQDVYRPKLSCGDV
YLKLTVSNGVLIVSFKEK
Download Length: 297 bp
>T135587 NZ_CP042359:18901-19197 [Rahnella aquatilis]
ATGGAAAAGAGAACTCCACATACGCGCCTTCATATCGTTCAGGGACTTGTTGCAGCAGGGAAGGTGAAAGCCACCAATAC
GGCGCTCAACGGCGCGGATAATTTAGGGCTGACATTTGATGATATGTGTAGCGCGATCCTGGGATTAACGGCAGCTGATT
TTTTTAAAAGTATGACCACCTATAATGATCATACTGTCTGGCAGGACGTATATCGCCCGAAGTTGTCGTGTGGTGACGTA
TATCTAAAACTAACGGTCAGTAACGGTGTTTTGATCGTCTCATTCAAGGAGAAGTAA
ATGGAAAAGAGAACTCCACATACGCGCCTTCATATCGTTCAGGGACTTGTTGCAGCAGGGAAGGTGAAAGCCACCAATAC
GGCGCTCAACGGCGCGGATAATTTAGGGCTGACATTTGATGATATGTGTAGCGCGATCCTGGGATTAACGGCAGCTGATT
TTTTTAAAAGTATGACCACCTATAATGATCATACTGTCTGGCAGGACGTATATCGCCCGAAGTTGTCGTGTGGTGACGTA
TATCTAAAACTAACGGTCAGTAACGGTGTTTTGATCGTCTCATTCAAGGAGAAGTAA
Antitoxin
Download Length: 134 a.a. Molecular weight: 14994.44 Da Isoelectric Point: 8.1347
>AT135587 WP_217137595.1 NZ_CP042359:19199-19600 [Rahnella aquatilis]
MKCSVCGGAELEFGIKKVPYSFRGRKTVIEAEGDHCPACGEVVMDREQSMAYMEKVKSFKAKIIAETIEPEYIIQVRKKL
ELTQKEASEIFGGGVNAFSRYEKGKAQPHPSIIKLLRVLDHHPELLDEVRKQA
MKCSVCGGAELEFGIKKVPYSFRGRKTVIEAEGDHCPACGEVVMDREQSMAYMEKVKSFKAKIIAETIEPEYIIQVRKKL
ELTQKEASEIFGGGVNAFSRYEKGKAQPHPSIIKLLRVLDHHPELLDEVRKQA
Download Length: 402 bp
>AT135587 NZ_CP042359:19199-19600 [Rahnella aquatilis]
ATGAAATGTTCCGTTTGTGGCGGTGCAGAACTTGAGTTTGGTATCAAAAAAGTCCCTTACTCATTCCGTGGCCGTAAAAC
AGTTATCGAGGCAGAAGGTGACCACTGTCCGGCGTGTGGTGAAGTCGTGATGGATCGTGAGCAGTCTATGGCCTACATGG
AAAAGGTGAAGTCATTTAAGGCCAAAATCATTGCGGAAACCATCGAACCTGAGTACATCATTCAGGTGCGTAAAAAACTT
GAACTCACGCAGAAAGAGGCCAGCGAGATTTTTGGCGGGGGCGTGAATGCCTTTTCGCGTTATGAAAAGGGTAAGGCACA
GCCACACCCTTCGATCATCAAACTCCTGCGCGTACTCGATCACCATCCCGAGTTATTGGATGAAGTGCGCAAACAGGCAT
AA
ATGAAATGTTCCGTTTGTGGCGGTGCAGAACTTGAGTTTGGTATCAAAAAAGTCCCTTACTCATTCCGTGGCCGTAAAAC
AGTTATCGAGGCAGAAGGTGACCACTGTCCGGCGTGTGGTGAAGTCGTGATGGATCGTGAGCAGTCTATGGCCTACATGG
AAAAGGTGAAGTCATTTAAGGCCAAAATCATTGCGGAAACCATCGAACCTGAGTACATCATTCAGGTGCGTAAAAAACTT
GAACTCACGCAGAAAGAGGCCAGCGAGATTTTTGGCGGGGGCGTGAATGCCTTTTCGCGTTATGAAAAGGGTAAGGCACA
GCCACACCCTTCGATCATCAAACTCCTGCGCGTACTCGATCACCATCCCGAGTTATTGGATGAAGTGCGCAAACAGGCAT
AA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|