Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 16511..17163 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP042359 | ||
| Organism | Rahnella aquatilis strain H145 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | FS594_RS26085 | Protein ID | WP_235174829.1 |
| Coordinates | 16511..16852 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FS594_RS26090 | Protein ID | WP_235174831.1 |
| Coordinates | 16849..17163 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FS594_RS26055 (FS594_26230) | 11644..12531 | + | 888 | WP_014416681.1 | branched-chain amino acid ABC transporter permease | - |
| FS594_RS26060 (FS594_26235) | 12528..13307 | + | 780 | WP_014416680.1 | ABC transporter ATP-binding protein | - |
| FS594_RS26065 (FS594_26240) | 13304..14023 | + | 720 | WP_013578151.1 | ABC transporter ATP-binding protein | - |
| FS594_RS26070 (FS594_26245) | 14057..14896 | + | 840 | WP_235174826.1 | VOC family protein | - |
| FS594_RS26075 (FS594_26255) | 15475..15657 | + | 183 | Protein_16 | DUF905 family protein | - |
| FS594_RS26080 (FS594_26260) | 15999..16241 | + | 243 | WP_235174827.1 | hypothetical protein | - |
| FS594_RS26085 (FS594_26265) | 16511..16852 | + | 342 | WP_235174829.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FS594_RS26090 (FS594_26270) | 16849..17163 | + | 315 | WP_235174831.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| FS594_RS26095 (FS594_26280) | 17641..17880 | + | 240 | Protein_20 | LysR family transcriptional regulator | - |
| FS594_RS26100 (FS594_26285) | 17877..18125 | + | 249 | WP_217137598.1 | EexN family lipoprotein | - |
| FS594_RS26105 (FS594_26290) | 18261..18806 | + | 546 | WP_235174833.1 | hypothetical protein | - |
| FS594_RS26110 (FS594_26295) | 18901..19197 | + | 297 | WP_217137596.1 | type II toxin-antitoxin system MqsR family toxin | - |
| FS594_RS26115 (FS594_26300) | 19199..19600 | + | 402 | WP_217137595.1 | type II toxin-antitoxin system MqsA family antitoxin | - |
| FS594_RS26120 (FS594_26305) | 20287..20661 | + | 375 | WP_235174835.1 | hypothetical protein | - |
| FS594_RS26125 (FS594_26310) | 20671..20898 | + | 228 | WP_112198754.1 | hypothetical protein | - |
| FS594_RS26130 (FS594_26315) | 20945..21274 | + | 330 | WP_235174837.1 | hypothetical protein | - |
| FS594_RS26135 (FS594_26320) | 21389..21634 | + | 246 | WP_235174839.1 | hypothetical protein | - |
| FS594_RS26140 (FS594_26325) | 21688..22062 | + | 375 | WP_235174841.1 | DUF3085 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | mrkH / mrkJ / mrkF / mrkD / mrkC / mrkB / mrkA | 1..467533 | 467533 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13285.26 Da Isoelectric Point: 9.3808
>T135586 WP_235174829.1 NZ_CP042359:16511-16852 [Rahnella aquatilis]
MDAIFVELSVFEAKRADYLSDDQFKEFQQMLLKNPTSGDVIPHTGGLRKIRFTDARRGKGKRGGLRVIYYWWLERSHFLL
FAVYDKDQKDDLSRDEQDILRKMLELLKQGGTL
MDAIFVELSVFEAKRADYLSDDQFKEFQQMLLKNPTSGDVIPHTGGLRKIRFTDARRGKGKRGGLRVIYYWWLERSHFLL
FAVYDKDQKDDLSRDEQDILRKMLELLKQGGTL
Download Length: 342 bp
>T135586 NZ_CP042359:16511-16852 [Rahnella aquatilis]
ATGGACGCTATTTTTGTTGAGTTAAGCGTGTTCGAAGCAAAACGCGCTGATTATTTGTCGGATGATCAATTTAAAGAATT
TCAACAGATGTTGCTTAAGAACCCGACCAGCGGCGACGTTATCCCTCACACGGGTGGCCTGAGAAAAATCAGGTTTACTG
ACGCCCGCAGGGGGAAAGGCAAGCGCGGCGGCTTAAGGGTTATTTATTACTGGTGGCTTGAAAGGTCTCATTTTCTGCTC
TTTGCAGTTTATGATAAAGATCAGAAAGATGATCTCAGCCGAGACGAACAGGACATCTTACGTAAGATGTTAGAATTACT
GAAACAAGGGGGCACCTTATGA
ATGGACGCTATTTTTGTTGAGTTAAGCGTGTTCGAAGCAAAACGCGCTGATTATTTGTCGGATGATCAATTTAAAGAATT
TCAACAGATGTTGCTTAAGAACCCGACCAGCGGCGACGTTATCCCTCACACGGGTGGCCTGAGAAAAATCAGGTTTACTG
ACGCCCGCAGGGGGAAAGGCAAGCGCGGCGGCTTAAGGGTTATTTATTACTGGTGGCTTGAAAGGTCTCATTTTCTGCTC
TTTGCAGTTTATGATAAAGATCAGAAAGATGATCTCAGCCGAGACGAACAGGACATCTTACGTAAGATGTTAGAATTACT
GAAACAAGGGGGCACCTTATGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11947.75 Da Isoelectric Point: 10.0631
>AT135586 WP_235174831.1 NZ_CP042359:16849-17163 [Rahnella aquatilis]
MSNRNLFEELKQGMQDWSDYNAGKITLKTHTVSQKKNITMSPEELKAVREKLRLSQAVFADYLHTGITTYQNWEQGRAKP
NKQAMLLIRMVEKDPHTLGTLAAL
MSNRNLFEELKQGMQDWSDYNAGKITLKTHTVSQKKNITMSPEELKAVREKLRLSQAVFADYLHTGITTYQNWEQGRAKP
NKQAMLLIRMVEKDPHTLGTLAAL
Download Length: 315 bp
>AT135586 NZ_CP042359:16849-17163 [Rahnella aquatilis]
ATGAGTAATCGCAACCTTTTCGAAGAGTTAAAGCAGGGTATGCAGGACTGGAGCGACTATAACGCGGGCAAGATTACGCT
GAAGACGCATACCGTTTCGCAGAAAAAAAATATCACGATGTCGCCGGAAGAGTTGAAGGCAGTCCGCGAAAAATTGCGTC
TCTCTCAGGCTGTTTTTGCAGATTACCTGCATACCGGCATCACGACTTATCAGAACTGGGAGCAGGGCCGGGCGAAGCCA
AATAAACAAGCTATGCTCCTGATCCGTATGGTTGAAAAAGACCCGCACACATTGGGCACTCTCGCAGCCCTCTAA
ATGAGTAATCGCAACCTTTTCGAAGAGTTAAAGCAGGGTATGCAGGACTGGAGCGACTATAACGCGGGCAAGATTACGCT
GAAGACGCATACCGTTTCGCAGAAAAAAAATATCACGATGTCGCCGGAAGAGTTGAAGGCAGTCCGCGAAAAATTGCGTC
TCTCTCAGGCTGTTTTTGCAGATTACCTGCATACCGGCATCACGACTTATCAGAACTGGGAGCAGGGCCGGGCGAAGCCA
AATAAACAAGCTATGCTCCTGATCCGTATGGTTGAAAAAGACCCGCACACATTGGGCACTCTCGCAGCCCTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|