Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2778762..2779447 Replicon chromosome
Accession NZ_CP042357
Organism Rahnella aquatilis strain H145

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FS594_RS12780 Protein ID WP_129951460.1
Coordinates 2778762..2779046 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FS594_RS12785 Protein ID WP_129951461.1
Coordinates 2779130..2779447 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FS594_RS12770 (FS594_12835) 2775640..2776659 + 1020 WP_129951458.1 transporter -
FS594_RS12775 (FS594_12840) 2776681..2778384 - 1704 WP_129951459.1 chloride channel protein -
FS594_RS12780 (FS594_12845) 2778762..2779046 + 285 WP_129951460.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FS594_RS12785 (FS594_12850) 2779130..2779447 + 318 WP_129951461.1 HigA family addiction module antitoxin Antitoxin
FS594_RS12790 (FS594_12855) 2779555..2780232 - 678 WP_129951462.1 ATP-binding cassette domain-containing protein -
FS594_RS12795 (FS594_12860) 2780225..2781109 - 885 WP_217137384.1 ABC transporter ATP-binding protein -
FS594_RS12800 (FS594_12865) 2781099..2781977 - 879 WP_129951464.1 ABC transporter permease -
FS594_RS12805 (FS594_12870) 2781983..2783035 - 1053 WP_235172909.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-89)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-84)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11323.99 Da        Isoelectric Point: 8.4613

>T135573 WP_129951460.1 NZ_CP042357:2778762-2779046 [Rahnella aquatilis]
MNDMLRISSFRDQWLEDFFHFATPHRKIPWTLATALERKLDMINAAMDYRDLLWPPGNRYEDLAAPLKGFSSIRVNEQYR
LIFYWREGKAHGLY

Download         Length: 285 bp

>T135573 NZ_CP042357:2778762-2779046 [Rahnella aquatilis]
ATGAACGATATGCTCAGGATAAGCAGTTTCCGCGATCAATGGCTGGAAGACTTTTTTCACTTCGCCACTCCCCATCGCAA
AATACCCTGGACGCTGGCAACCGCTCTGGAAAGGAAGCTGGATATGATCAATGCCGCAATGGATTATCGGGATTTACTCT
GGCCTCCGGGCAATCGCTACGAAGATCTGGCAGCTCCGTTAAAGGGATTTTCATCGATCAGGGTGAATGAACAGTACCGT
CTGATTTTTTACTGGCGGGAAGGCAAAGCACATGGCCTGTATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12178.11 Da        Isoelectric Point: 8.6579

>AT135573 WP_129951461.1 NZ_CP042357:2779130-2779447 [Rahnella aquatilis]
MAVTTRKPATVGDILLYEFLEPTGLRINDLADMLNVHRNTISALVNNNRKLTVDIAFRLAKTFETSVEFWLNLQTHVDIW
EVRNNPRLMDDINKVVHLKDFLKKS

Download         Length: 318 bp

>AT135573 NZ_CP042357:2779130-2779447 [Rahnella aquatilis]
ATGGCTGTGACCACACGTAAACCCGCTACCGTTGGTGATATTTTACTTTACGAATTTCTTGAGCCCACTGGCCTGCGGAT
CAACGATCTTGCCGACATGCTGAATGTTCACCGCAATACCATCAGCGCACTGGTGAATAACAACCGCAAGCTGACCGTTG
ATATCGCCTTCCGGCTGGCAAAGACATTTGAGACTTCTGTCGAATTCTGGTTAAACCTGCAAACCCATGTCGATATCTGG
GAAGTGCGCAATAACCCGCGCCTGATGGATGACATCAACAAGGTCGTTCATCTGAAAGATTTTCTGAAAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References