Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 1421531..1421902 | Replicon | chromosome |
| Accession | NZ_CP042352 | ||
| Organism | Escherichia coli strain RM9513 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | A0A7W3G0W6 |
| Locus tag | FS836_RS07250 | Protein ID | WP_072130784.1 |
| Coordinates | 1421708..1421902 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 1421531..1421709 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FS836_RS07225 (1417486) | 1417486..1418859 | + | 1374 | WP_000123737.1 | ATP-dependent RNA helicase DbpA | - |
| FS836_RS07230 (1418988) | 1418988..1419923 | - | 936 | WP_001157377.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
| FS836_RS07235 (1419975) | 1419975..1421210 | - | 1236 | WP_265467720.1 | site-specific integrase | - |
| FS836_RS07240 (1421212) | 1421212..1421427 | - | 216 | WP_000079604.1 | excisionase XisR | - |
| - (1421531) | 1421531..1421709 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1421531) | 1421531..1421709 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1421531) | 1421531..1421709 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (1421531) | 1421531..1421709 | + | 179 | NuclAT_0 | - | Antitoxin |
| FS836_RS07245 (1421527) | 1421527..1421715 | - | 189 | WP_001302840.1 | DUF1187 family protein | - |
| FS836_RS07250 (1421708) | 1421708..1421902 | - | 195 | WP_072130784.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| FS836_RS07255 (1421959) | 1421959..1422792 | - | 834 | WP_047671513.1 | recombination protein RecT | - |
| FS836_RS07260 (1422785) | 1422785..1425436 | - | 2652 | WP_137445568.1 | exodeoxyribonuclease VIII | - |
| FS836_RS07265 (1425538) | 1425538..1425813 | - | 276 | WP_032218014.1 | hypothetical protein | - |
| FS836_RS07270 (1425888) | 1425888..1426064 | - | 177 | WP_032218016.1 | YdaE family protein | - |
| FS836_RS07275 (1426058) | 1426058..1426279 | - | 222 | WP_000560226.1 | killing protein KilR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1419975..1460475 | 40500 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7135.00 Da Isoelectric Point: 8.0115
>T135518 WP_072130784.1 NZ_CP042352:c1421902-1421708 [Escherichia coli]
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV
MRYDDVKPCPFCGCPSVTVKDISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTENINGGVHV
Download Length: 195 bp
>T135518 NZ_CP042352:c1421902-1421708 [Escherichia coli]
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA
TTGAGATATGACGATGTTAAACCATGTCCGTTTTGTGGTTGTCCATCAGTAACGGTGAAAGACATTTCAGGATATTACCG
GGCAAAATGCAACGGATGCGAATCCCGAACTGGCTATGGTGGAAGTGAAAAAGAAGCGCTCGAAAGATGGAATAAACGAA
CCACTGAAAATATTAATGGAGGCGTTCATGTATAA
Antitoxin
Download Length: 179 bp
>AT135518 NZ_CP042352:1421531-1421709 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATTGTAGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
