Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2515127..2515311 Replicon chromosome
Accession NZ_CP042348
Organism Staphylococcus aureus strain BSN9R

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag FSN22_RS12890 Protein ID WP_000482650.1
Coordinates 2515204..2515311 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2515127..2515187 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSN22_RS12875 2510657..2510824 - 168 WP_001790576.1 hypothetical protein -
FSN22_RS12880 2511055..2512788 - 1734 WP_147032798.1 ABC transporter ATP-binding protein/permease -
FSN22_RS12885 2512813..2514576 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2515127..2515187 + 61 - - Antitoxin
FSN22_RS12890 2515204..2515311 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
FSN22_RS12895 2515445..2515831 - 387 WP_000779358.1 flippase GtxA -
FSN22_RS12900 2516099..2517241 + 1143 WP_001176863.1 glycerate kinase -
FSN22_RS12905 2517301..2517960 + 660 WP_000831298.1 membrane protein -
FSN22_RS12910 2518142..2519353 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
FSN22_RS12915 2519476..2519949 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T135484 WP_000482650.1 NZ_CP042348:c2515311-2515204 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T135484 NZ_CP042348:c2515311-2515204 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT135484 NZ_CP042348:2515127-2515187 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References