Detailed information of TA system TA135475

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2050283..2050582
• Replicon: chromosome
• Accession: NZ_CP042348
• Organism: Staphylococcus aureus strain BSN9R

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: FSN22_RS10355
• Protein ID: WP_011447039.1
• Coordinates: 2050406..2050582 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2050283..2050338 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FSN22_RS10310	2045614..2045874	+	261	WP_001791826.1	hypothetical protein	-
FSN22_RS10315	2045927..2046277	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
FSN22_RS10320	2046962..2047411	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
FSN22_RS10325	2047506..2047841	-	336	Protein_1940	SH3 domain-containing protein	-
FSN22_RS10335	2048491..2048982	-	492	WP_000919350.1	staphylokinase	-
FSN22_RS10340	2049173..2049928	-	756	WP_000861038.1	CHAP domain-containing protein	-
FSN22_RS10345	2049940..2050194	-	255	WP_000611512.1	phage holin	-
FSN22_RS10350	2050246..2050353	+	108	WP_001791821.1	hypothetical protein	-
-	2050275..2050414	+	140	NuclAT_0	-	-
-	2050275..2050414	+	140	NuclAT_0	-	-
-	2050275..2050414	+	140	NuclAT_0	-	-
-	2050275..2050414	+	140	NuclAT_0	-	-
-	2050283..2050338	+	56	-	-	Antitoxin
FSN22_RS10355	2050406..2050582	-	177	WP_011447039.1	putative holin-like toxin	Toxin
FSN22_RS10360	2050732..2051028	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
FSN22_RS10365	2051086..2051373	-	288	WP_001040261.1	hypothetical protein	-
FSN22_RS10370	2051420..2051572	-	153	WP_001153681.1	hypothetical protein	-
FSN22_RS10375	2051562..2055347	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2045927..2104894	58967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T135475 WP_011447039.1 NZ_CP042348:c2050582-2050406 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T135475 NZ_CP042348:c2050582-2050406 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT135475 NZ_CP042348:2050283-2050338 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin