Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2489779..2490296 Replicon chromosome
Accession NZ_CP042346
Organism Staphylococcus aureus strain BSN9S

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag FSN21_RS12750 Protein ID WP_000113262.1
Coordinates 2489779..2490045 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag FSN21_RS12755 Protein ID WP_000584502.1
Coordinates 2490045..2490296 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSN21_RS12720 2485205..2485741 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
FSN21_RS12725 2485974..2486798 - 825 WP_000572040.1 formate/nitrite transporter family protein -
FSN21_RS12730 2487015..2487197 - 183 WP_000230294.1 hypothetical protein -
FSN21_RS12735 2487281..2487748 - 468 WP_000153344.1 SRPBCC domain-containing protein -
FSN21_RS12740 2487934..2489484 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FSN21_RS12745 2489673..2489744 - 72 Protein_2404 hypothetical protein -
FSN21_RS12750 2489779..2490045 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
FSN21_RS12755 2490045..2490296 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FSN21_RS12760 2490461..2490562 - 102 WP_001791744.1 hypothetical protein -
FSN21_RS12765 2490569..2491168 - 600 WP_000162813.1 DsbA family protein -
FSN21_RS12770 2491187..2491546 - 360 WP_000819847.1 DUF4467 domain-containing protein -
FSN21_RS12775 2491801..2493051 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
FSN21_RS12780 2493148..2493879 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
FSN21_RS12785 2493876..2494595 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T135467 WP_000113262.1 NZ_CP042346:c2490045-2489779 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T135467 NZ_CP042346:c2490045-2489779 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT135467 WP_000584502.1 NZ_CP042346:c2490296-2490045 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT135467 NZ_CP042346:c2490296-2490045 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References