Detailed information of TA system TA135466

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2224950..2225167
• Replicon: chromosome
• Accession: NZ_CP042346
• Organism: Staphylococcus aureus strain BSN9S

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: FSN21_RS11360
• Protein ID: WP_001802298.1
• Coordinates: 2225063..2225167 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2224950..2225005 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FSN21_RS11340	2221087..2221752	-	666	WP_001024094.1	SDR family oxidoreductase	-
FSN21_RS11345	2221904..2222224	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
FSN21_RS11350	2222226..2223206	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
FSN21_RS11355	2223472..2224563	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2224950..2225005	+	56	-	-	Antitoxin
FSN21_RS11360	2225063..2225167	-	105	WP_001802298.1	hypothetical protein	Toxin
FSN21_RS11365	2225328..2225811	-	484	Protein_2138	recombinase family protein	-
FSN21_RS11370	2225854..2226990	-	1137	WP_000115564.1	SAP domain-containing protein	-
FSN21_RS11375	2227279..2227371	+	93	WP_001790138.1	hypothetical protein	-
FSN21_RS11380	2228076..2228933	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
FSN21_RS11385	2229001..2229783	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T135466 WP_001802298.1 NZ_CP042346:c2225167-2225063 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T135466 NZ_CP042346:c2225167-2225063 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT135466 NZ_CP042346:2224950-2225005 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin