Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 238268..238787 Replicon chromosome
Accession NZ_CP042341
Organism Staphylococcus capitis strain BN2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A507SVT5
Locus tag FRG19_RS00980 Protein ID WP_002436254.1
Coordinates 238268..238537 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1J4EAU6
Locus tag FRG19_RS00985 Protein ID WP_002436168.1
Coordinates 238530..238787 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRG19_RS00960 233429..235132 + 1704 WP_194251355.1 YSIRK-type signal peptide-containing protein -
FRG19_RS00965 235246..236004 + 759 WP_030059220.1 esterase family protein -
FRG19_RS00970 236547..237695 + 1149 WP_172969460.1 CapA family protein -
FRG19_RS00975 237759..238124 - 366 WP_002436243.1 DUF4870 domain-containing protein -
FRG19_RS00980 238268..238537 - 270 WP_002436254.1 Txe/YoeB family addiction module toxin Toxin
FRG19_RS00985 238530..238787 - 258 WP_002436168.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FRG19_RS00990 238972..239829 + 858 WP_002454139.1 ABC transporter substrate-binding protein -
FRG19_RS00995 239939..241579 - 1641 WP_194251356.1 alpha-keto acid decarboxylase family protein -
FRG19_RS01000 241752..242207 + 456 WP_002436214.1 MarR family winged helix-turn-helix transcriptional regulator -
FRG19_RS01005 242840..243190 - 351 WP_095323983.1 hypothetical protein -
FRG19_RS01010 243218..243517 - 300 WP_194251357.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10524.00 Da        Isoelectric Point: 9.7885

>T135439 WP_002436254.1 NZ_CP042341:c238537-238268 [Staphylococcus capitis]
MSKFSVTFTAQAFKDYQYWQQHNQNYFKKVNALLKSIARDGCVDGIGKPEALKGNYEGYFSRRVSIEHRLIYKIKDDSIF
VVSCRFHYQ

Download         Length: 270 bp

>T135439 NZ_CP042341:c238537-238268 [Staphylococcus capitis]
ATGAGTAAGTTTAGTGTAACTTTTACAGCTCAAGCATTTAAAGATTATCAATATTGGCAACAACACAATCAAAATTATTT
TAAAAAAGTGAATGCTTTACTTAAAAGTATTGCAAGAGATGGTTGTGTCGATGGTATTGGAAAACCAGAAGCATTAAAAG
GAAACTACGAAGGCTATTTCAGTAGAAGAGTTTCAATAGAACACCGATTAATATACAAAATTAAGGATGATTCAATATTC
GTAGTGTCTTGCAGATTTCATTATCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9737.79 Da        Isoelectric Point: 4.1359

>AT135439 WP_002436168.1 NZ_CP042341:c238787-238530 [Staphylococcus capitis]
MPSVNYSNARQNFKELITKVNEDSVAYTITTKENENAVILAEKDYNAMLETMYLQSNLANVSHLNQSIMELNHNQTITIE
IDDNE

Download         Length: 258 bp

>AT135439 NZ_CP042341:c238787-238530 [Staphylococcus capitis]
ATGCCTTCAGTTAATTATTCAAACGCTAGACAGAATTTCAAAGAACTTATTACTAAAGTGAACGAGGATAGTGTGGCTTA
CACTATTACGACAAAGGAAAATGAAAATGCAGTGATTTTAGCTGAAAAGGATTATAATGCGATGTTGGAAACGATGTACC
TTCAATCCAATCTCGCTAATGTGTCTCACTTAAATCAATCAATTATGGAATTGAATCATAACCAAACAATTACAATAGAG
ATTGATGATAATGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A507SVT5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4EAU6

References