Detailed information of TA system TA135393

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 2405946..2406460
• Replicon: chromosome
• Accession: NZ_CP042324
• Organism: Streptomyces coelicolor A3(2) strain CFB_NBC_0001

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: Q9Z4V8
• Locus tag: FQ762_RS11425
• Protein ID: WP_003976577.1
• Coordinates: 2406206..2406460 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q9Z4V7
• Locus tag: FQ762_RS11420
• Protein ID: WP_003976578.1
• Coordinates: 2405946..2406209 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQ762_RS11405	2401778..2402647	+	870	WP_003976581.1	phosphatase PAP2 family protein	-
FQ762_RS11410	2402773..2405772	-	3000	WP_011028215.1	bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase	-
FQ762_RS11420	2405946..2406209	+	264	WP_003976578.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
FQ762_RS11425	2406206..2406460	+	255	WP_003976577.1	Txe/YoeB family addiction module toxin	Toxin
FQ762_RS11430	2406523..2406969	+	447	WP_003976576.1	VOC family protein	-
FQ762_RS11435	2406992..2408761	-	1770	WP_037666705.1	NAD+ synthase	-
FQ762_RS11440	2408844..2409470	-	627	WP_011028217.1	DUF305 domain-containing protein	-
FQ762_RS11445	2409467..2410135	-	669	WP_011028218.1	DUF3105 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9954.26 Da
• Isoelectric Point: 9.7377

>T135393 WP_003976577.1 NZ_CP042324:2406206-2406460 [Streptomyces coelicolor A3(2)]
VRITFTSHGWEDYVHWAESDRKVTKRINRLIADIARDPFKGVGKPEPLKGDLSGYWSRRIDDTHRLVYKPTDDQLVIVQA
RYHY

Nucleotide

• Length: 255 bp

>T135393 NZ_CP042324:2406206-2406460 [Streptomyces coelicolor A3(2)]
GTGAGGATCACTTTCACGTCCCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTGACCAAGCGGAT
CAACAGACTGATCGCCGACATCGCCCGTGACCCGTTCAAGGGCGTCGGCAAGCCGGAGCCGCTCAAGGGCGACCTGTCCG
GCTACTGGTCACGGCGCATCGACGACACGCACCGTCTTGTGTACAAGCCCACCGATGACCAGCTGGTCATCGTCCAGGCG
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9692.69 Da
• Isoelectric Point: 4.4149

>AT135393 WP_003976578.1 NZ_CP042324:2405946-2406209 [Streptomyces coelicolor A3(2)]
MSITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPRNARRLLDSIAEAEAGDATEHDLI
DPDAERA

Nucleotide

• Length: 264 bp

>AT135393 NZ_CP042324:2405946-2406209 [Streptomyces coelicolor A3(2)]
ATGTCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCACGCCCCGGTGCA
CATCACCTCCCGCAAGGGGAACGCCGTGCTCATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCATCTCCTGC
GCTCGCCGAGGAACGCCCGCCGTCTGCTCGACTCCATCGCGGAGGCCGAGGCGGGCGACGCGACTGAGCACGACCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Structures

Toxin

• AlphaFold DB: Q9Z4V8

Antitoxin

• AlphaFold DB: Q9Z4V7