Detailed information of TA system TA135213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 60075..60673
• Replicon: chromosome
• Accession: NZ_CP042304
• Organism: Devosia ginsengisoli strain Gsoil 520

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FPZ08_RS00325
• Protein ID: WP_146288144.1
• Coordinates: 60075..60398 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FPZ08_RS00330
• Protein ID: WP_186767303.1
• Coordinates: 60428..60673 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FPZ08_RS00310	55760..56806	-	1047	WP_146288142.1	extracellular solute-binding protein	-
FPZ08_RS00315	57005..59530	-	2526	WP_146288143.1	hypothetical protein	-
FPZ08_RS00325	60075..60398	+	324	WP_146288144.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FPZ08_RS00330	60428..60673	+	246	WP_186767303.1	helix-turn-helix domain-containing protein	Antitoxin
FPZ08_RS00335	60670..60897	+	228	WP_146288146.1	hypothetical protein	-
FPZ08_RS00340	60986..62764	-	1779	WP_146288147.1	pilus assembly protein	-
FPZ08_RS00345	62830..63453	-	624	WP_146288148.1	L,D-transpeptidase	-
FPZ08_RS00350	63597..63992	-	396	WP_186767144.1	response regulator	-
FPZ08_RS00355	64169..64792	+	624	WP_146288150.1	DNA-3-methyladenine glycosylase I	-
FPZ08_RS00360	65130..65390	+	261	WP_146288151.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (26-71)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12253.58 Da
• Isoelectric Point: 10.3951

>T135213 WP_146288144.1 NZ_CP042304:60075-60398 [Devosia ginsengisoli]
MKWTVETLDVADAEIEALPPALQARLLRLMEMVEMVGLEQLREPHVKHIDGKLWELRAKATEGIARGLYVTMTGRRVVIL
HVFVKKSRKTPRNALDIALERMKQVTP

Nucleotide

• Length: 324 bp

>T135213 NZ_CP042304:60075-60398 [Devosia ginsengisoli]
ATGAAATGGACGGTTGAAACCCTCGATGTAGCCGATGCTGAAATCGAGGCATTGCCGCCCGCACTGCAGGCCCGGCTTCT
CCGCCTCATGGAAATGGTGGAGATGGTCGGTCTGGAGCAATTGCGCGAGCCCCACGTCAAGCACATCGACGGCAAGTTGT
GGGAGTTGCGTGCCAAGGCGACGGAAGGGATTGCGCGCGGTCTCTATGTGACGATGACCGGGCGCCGCGTGGTCATCCTC
CACGTGTTCGTCAAGAAGTCCCGGAAGACGCCGCGCAATGCTCTGGATATTGCCCTGGAACGAATGAAGCAGGTGACGCC
GTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8729.95 Da
• Isoelectric Point: 7.0117

>AT135213 WP_186767303.1 NZ_CP042304:60428-60673 [Devosia ginsengisoli]
MDNPEFKAEYEKADAEFALVEALVLARTKAKLSQAELAKRIGTTQSAIARLEGGGVSPSLSTLKRYADATGSRLHIELVP
Q

Nucleotide

• Length: 246 bp

>AT135213 NZ_CP042304:60428-60673 [Devosia ginsengisoli]
ATGGACAATCCGGAGTTCAAGGCCGAATACGAGAAGGCCGATGCTGAGTTTGCACTTGTCGAAGCTCTGGTTCTGGCTCG
CACCAAGGCCAAGCTCTCTCAGGCCGAATTGGCCAAGCGGATTGGCACCACCCAATCGGCCATAGCCCGGCTTGAAGGGG
GTGGCGTATCACCCTCGCTGTCCACTCTGAAACGCTATGCCGATGCCACCGGCTCGCGCTTGCATATTGAGCTTGTGCCG
CAATGA