Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 884403..885018 | Replicon | chromosome |
| Accession | NZ_CP042300 | ||
| Organism | Vibrio cholerae O1 strain AAS91 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | Q9KMG5 |
| Locus tag | FKV26_RS17515 | Protein ID | WP_001162670.1 |
| Coordinates | 884731..885018 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FKV26_RS17510 | Protein ID | WP_001232701.1 |
| Coordinates | 884403..884720 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FKV26_RS17475 | 879552..880427 | - | 876 | WP_000259044.1 | hypothetical protein | - |
| FKV26_RS17480 | 880874..881350 | - | 477 | WP_148661834.1 | hypothetical protein | - |
| FKV26_RS17485 | 881407..882237 | - | 831 | WP_000056616.1 | abortive infection family protein | - |
| FKV26_RS17490 | 882442..883182 | - | 741 | WP_000469836.1 | PhzF family phenazine biosynthesis protein | - |
| FKV26_RS18990 | 883406..883444 | - | 39 | WP_106019119.1 | hypothetical protein | - |
| FKV26_RS18995 | 883460..883585 | - | 126 | WP_001944767.1 | DUF645 family protein | - |
| FKV26_RS17500 | 883931..884101 | - | 171 | WP_001882300.1 | DUF645 family protein | - |
| FKV26_RS19000 | 884296..884406 | - | 111 | WP_134814058.1 | DUF3265 domain-containing protein | - |
| FKV26_RS17510 | 884403..884720 | - | 318 | WP_001232701.1 | HigA family addiction module antidote protein | Antitoxin |
| FKV26_RS17515 | 884731..885018 | - | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FKV26_RS17520 | 885285..885465 | - | 181 | Protein_814 | DUF645 family protein | - |
| FKV26_RS17525 | 885890..886123 | - | 234 | Protein_815 | DUF3709 domain-containing protein | - |
| FKV26_RS17530 | 886526..886744 | - | 219 | WP_001917086.1 | DUF3709 domain-containing protein | - |
| FKV26_RS17535 | 887054..887707 | - | 654 | WP_000226874.1 | hypothetical protein | - |
| FKV26_RS17540 | 887764..888273 | - | 510 | WP_000405986.1 | GNAT family N-acetyltransferase | - |
| FKV26_RS17545 | 888515..888757 | + | 243 | WP_000557292.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| FKV26_RS17550 | 888776..889093 | + | 318 | WP_001180243.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| FKV26_RS17555 | 889108..889230 | - | 123 | WP_080033517.1 | DUF3265 domain-containing protein | - |
| FKV26_RS17560 | 889252..889470 | - | 219 | WP_001209280.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | catB9 | - | 827249..947639 | 120390 | |
| - | inside | Integron | - | - | 828494..941258 | 112764 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11349.95 Da Isoelectric Point: 6.7187
>T135204 WP_001162670.1 NZ_CP042300:c885018-884731 [Vibrio cholerae O1]
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
MALEFKDKWLEQFYEDDKRHRLIPSSIENALFRKLEILDAAQAESDLRIPPGNRFEHLEGNLKGWCSIRVNKQYRLIFQW
VDGVALNTYLDPHKY
Download Length: 288 bp
>T135204 NZ_CP042300:c885018-884731 [Vibrio cholerae O1]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCTCAAGCTGAATCAGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11705.63 Da Isoelectric Point: 10.4711
>AT135204 WP_001232701.1 NZ_CP042300:c884720-884403 [Vibrio cholerae O1]
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
MRKTKRRPVSVGEMLKVEFLEPMGITSKALAEAMGVHRNTVSNLINGGVLTAPVAIKLAAALGNTPEFWLNIQHAVDLWD
TRNRYQEEAKFVKPLFVSLEQSART
Download Length: 318 bp
>AT135204 NZ_CP042300:c884720-884403 [Vibrio cholerae O1]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTCAGTAATTTAATTAATGGTGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCCGCGGCATTAGGTAACACACCAGAATTTTGGCTTAACATTCAACATGCAGTTGATCTTTGGGAT
ACGAGAAATCGTTATCAAGAAGAAGCAAAGTTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|