Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1176502..1177172 Replicon chromosome
Accession NZ_CP042260
Organism Glutamicibacter halophytocola strain DR408

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag FQA45_RS05475 Protein ID WP_146275615.1
Coordinates 1176813..1177172 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag FQA45_RS05470 Protein ID WP_060703428.1
Coordinates 1176502..1176807 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQA45_RS05445 1172334..1173287 + 954 WP_146275605.1 alpha/beta hydrolase -
FQA45_RS05450 1173297..1173881 + 585 WP_146275607.1 YdeI/OmpD-associated family protein -
FQA45_RS05455 1174159..1174563 - 405 WP_146275609.1 hypothetical protein -
FQA45_RS05460 1175444..1175980 - 537 WP_146275611.1 isochorismatase family protein -
FQA45_RS05465 1175980..1176282 - 303 WP_146275613.1 HigA family addiction module antidote protein -
FQA45_RS05470 1176502..1176807 - 306 WP_060703428.1 helix-turn-helix domain-containing protein Antitoxin
FQA45_RS05475 1176813..1177172 - 360 WP_146275615.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FQA45_RS05480 1177316..1178401 - 1086 WP_146275617.1 redox-regulated ATPase YchF -
FQA45_RS05485 1178463..1179560 - 1098 WP_060702139.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
FQA45_RS05490 1179661..1180854 - 1194 WP_146275619.1 SH3 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-93)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13544.45 Da        Isoelectric Point: 4.6921

>T135118 WP_146275615.1 NZ_CP042260:c1177172-1176813 [Glutamicibacter halophytocola]
MWNVDIELIELIEVWLAELDVDSREQVVAAIELLEDSGPQLGRPIVDTVKASRHKNIKELRPGSSGKSELRILFAFDPER
AAIMLIAGDKAGDWQGWYEKNLPHADRLFDEHLDKIRGK

Download         Length: 360 bp

>T135118 NZ_CP042260:c1177172-1176813 [Glutamicibacter halophytocola]
TTGTGGAACGTGGACATCGAGCTCATCGAGCTCATCGAGGTTTGGCTTGCTGAGCTTGATGTTGATTCCCGGGAGCAAGT
GGTTGCCGCGATTGAACTGCTAGAGGATTCTGGGCCCCAGCTCGGACGACCCATTGTGGACACCGTAAAAGCATCTCGCC
ATAAGAATATAAAGGAACTTCGACCAGGTTCATCTGGCAAATCAGAATTGCGAATCTTGTTTGCGTTCGATCCGGAGCGG
GCGGCAATCATGCTAATTGCGGGCGATAAAGCTGGTGACTGGCAAGGCTGGTACGAGAAAAACCTTCCACATGCCGATCG
ATTGTTCGATGAACATTTAGACAAGATAAGAGGAAAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11550.22 Da        Isoelectric Point: 8.5142

>AT135118 WP_060703428.1 NZ_CP042260:c1176807-1176502 [Glutamicibacter halophytocola]
MAKSLKDFLAQNPVDRDRVEKHKQRMLAEVRAYRLRELREQAGLTQAELAERIGVGQRQVSKIEHGDLENAKIGTIRNYL
EAVGGELSLEYLMGDQRMQIA

Download         Length: 306 bp

>AT135118 NZ_CP042260:c1176807-1176502 [Glutamicibacter halophytocola]
TTGGCCAAGTCTCTTAAGGACTTTCTCGCTCAGAATCCAGTCGATCGGGACCGGGTCGAGAAGCACAAGCAGAGAATGCT
TGCGGAGGTTCGTGCCTATCGCTTGCGCGAATTGCGTGAACAGGCTGGACTCACTCAAGCTGAGCTCGCTGAGCGCATTG
GTGTGGGGCAGCGTCAAGTCTCGAAGATTGAGCATGGAGATCTTGAGAATGCAAAAATCGGCACAATCCGCAACTATTTG
GAAGCTGTCGGAGGGGAGCTGTCCTTGGAATACCTGATGGGCGATCAGCGGATGCAGATAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References