Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3545367..3546610 Replicon chromosome
Accession NZ_CP042254
Organism Legionella longbeachae strain B3526CHC

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag FQU71_RS16425 Protein ID WP_150867211.1
Coordinates 3545672..3546610 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag FQU71_RS16420 Protein ID WP_010948073.1
Coordinates 3545367..3545675 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU71_RS16400 3541586..3541945 - 360 Protein_3044 TraK family protein -
FQU71_RS16405 3542263..3544014 - 1752 WP_150867209.1 DUF927 domain-containing protein -
FQU71_RS16410 3544080..3544355 - 276 WP_058478704.1 DNA-binding protein -
FQU71_RS16415 3545143..3545370 + 228 WP_006870829.1 helix-turn-helix transcriptional regulator -
FQU71_RS16420 3545367..3545675 + 309 WP_010948073.1 HipA N-terminal domain-containing protein Antitoxin
FQU71_RS16425 3545672..3546610 + 939 WP_150867211.1 lpg2370 family Dot/Icm T4SS effector Toxin
FQU71_RS16430 3546607..3547839 - 1233 WP_106184167.1 integrase family protein -
FQU71_RS16435 3548085..3548300 - 216 Protein_3051 transposase family protein -
FQU71_RS16445 3548658..3548873 + 216 WP_003634934.1 hypothetical protein -
FQU71_RS16450 3549161..3550585 + 1425 WP_150867213.1 IS4 family transposase -
FQU71_RS16455 3550526..3551138 - 613 Protein_3054 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3549161..3550585 1424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35997.77 Da        Isoelectric Point: 8.9257

>T135117 WP_150867211.1 NZ_CP042254:3545672-3546610 [Legionella longbeachae]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGVSFLSQPMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

>T135117 NZ_CP042254:3545672-3546610 [Legionella longbeachae]
ATGAAACACTGCCCTATTACTTATGAAAAGATTAGTGACCAGGAAAACTATTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAACCTTAGTCCATTGGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTGTTCAAGGCGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAAGGCTGTTTTGAAATCGTGGATCAATATGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTAACCTACTTCATTAAACGCTTTGATA
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTAATTGCAGTCATAGAACAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCTTGGTCGGTAATGAAGACATGCATCTAAAAAACTTTTCCTTAATTACGAAGGATAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACCATCGCTCAAAAAAATACCAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCATTGAAAAATTAGGATTAAACCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGTGTCAGTTTTTTATCTCAACCGATGC
AGGAAAAATATCTCGAATTGCTAGAGCAACGGTGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT135117 WP_010948073.1 NZ_CP042254:3545367-3545675 [Legionella longbeachae]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT135117 NZ_CP042254:3545367-3545675 [Legionella longbeachae]
ATGAGAAAAGCATACGTATCGGTGAGTGGCATTAAGGCTGGAATATTAGAAGAATTACAAGGTGGAACCTATCAATTTAC
CTACTTTGAGGATTATCACGGCGCACCTGTTTCACTCACTATGCCGTTGAAAAATAAGGTCTATGATTTTGACGTGTTCC
CCCCTTTTTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATACAAGATAGATAAAAATGAT
TATTTTGGTCAATTGATACTAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 7VKB
AlphaFold DB Q5ZSZ7

References