Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3545367..3546610 Replicon chromosome
Accession NZ_CP042254
Organism Legionella longbeachae strain B3526CHC

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag FQU71_RS16425 Protein ID WP_150867211.1
Coordinates 3545672..3546610 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID Q5ZSZ7
Locus tag FQU71_RS16420 Protein ID WP_010948073.1
Coordinates 3545367..3545675 (+) Length 103 a.a.

Genomic Context

FQU71_RS16415FQU71_RS16420FQU71_RS16425FQU71_RS16445FQU71_RS16450FQU71_RS16400FQU71_RS16405FQU71_RS16410FQU71_RS16430FQU71_RS16435FQU71_RS16455
Location: 3545143..3545370 (228 bp)
Type: Others
Protein ID: WP_006870829.1
Location: 3545367..3545675 (309 bp)
Type: Antitoxin
Protein ID: WP_010948073.1
Location: 3545672..3546610 (939 bp)
Type: Toxin
Protein ID: WP_150867211.1
Location: 3548658..3548873 (216 bp)
Type: Others
Protein ID: WP_003634934.1
Location: 3549161..3550585 (1425 bp)
Type: Others
Protein ID: WP_150867213.1
Location: 3541586..3541945 (360 bp)
Type: Others
Protein ID: Protein_3044
Location: 3542263..3544014 (1752 bp)
Type: Others
Protein ID: WP_150867209.1
Location: 3544080..3544355 (276 bp)
Type: Others
Protein ID: WP_058478704.1
Location: 3546607..3547839 (1233 bp)
Type: Others
Protein ID: WP_106184167.1
Location: 3548085..3548300 (216 bp)
Type: Others
Protein ID: Protein_3051
Location: 3550526..3551138 (613 bp)
Type: Others
Protein ID: Protein_3054
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
FQU71_RS164003541586..3541945-360Protein_3044TraK family protein-
FQU71_RS164053542263..3544014-1752WP_150867209.1DUF927 domain-containing protein-
FQU71_RS164103544080..3544355-276WP_058478704.1DNA-binding protein-
FQU71_RS164153545143..3545370+228WP_006870829.1helix-turn-helix transcriptional regulator-
FQU71_RS164203545367..3545675+309WP_010948073.1HipA N-terminal domain-containing proteinAntitoxin
FQU71_RS164253545672..3546610+939WP_150867211.1lpg2370 family Dot/Icm T4SS effectorToxin
FQU71_RS164303546607..3547839-1233WP_106184167.1integrase family protein-
FQU71_RS164353548085..3548300-216Protein_3051transposase family protein-
FQU71_RS164453548658..3548873+216WP_003634934.1hypothetical protein-
FQU71_RS164503549161..3550585+1425WP_150867213.1IS4 family transposase-
FQU71_RS164553550526..3551138-613Protein_3054universal stress protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-flankIS/Tn--3549161..35505851424


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-276)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35997.77 Da        Isoelectric Point: 8.9257

>T135117 WP_150867211.1 NZ_CP042254:3545672-3546610 [Legionella longbeachae]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGVSFLSQPMQEKYLELLEQRCKRLNFFD

Download         Length: 939 bp

>T135117 NZ_CP042254:3545672-3546610 [Legionella longbeachae]
ATGAAACACTGCCCTATTACTTATGAAAAGATTAGTGACCAGGAAAACTATTCGCAACGTGGATTGCATTTGCTTTCTCC
TCAATTAAAAAACCTTAGTCCATTGGATTTAAGTGCTGATGAGCAGCGTCAGGAAGCAATTGCTCGAGTAGGAAAGATGT
CTGTTCAAGGCGTCCAAAAGAAACTAAGCGCAAAACTAAAGATTAAAGAAGGCTGTTTTGAAATCGTGGATCAATATGGT
CAGTATATTTTAAAACCACAAAGTGATATTTATCCAGAATTGCCTGAAAATGAAGCCATTACTATGACCCTTGCAAAAAC
TATAGGCCTCGAAGTTCCGGTTCATGGTTTGGTTTATTCTAAAGACAACAGTTTAACCTACTTCATTAAACGCTTTGATA
GAATAGGCCATAATAAAAAGTTAGCTTTAGAAGATTTTGCACAGCTATCAGGTGAAGATCGACATACAAAATATAAAAGT
TCTATGGAAAAAGTAATTGCAGTCATAGAACAGTTTTGTACATTCCCAAAAATTGAATTCGTGAAATTATTTAAGTTGAC
GTTGTTTAACTTCTTGGTCGGTAATGAAGACATGCATCTAAAAAACTTTTCCTTAATTACGAAGGATAGAAAAATTTCCA
TATCACCAGCCTACGATTTACTTAACTCAACCATCGCTCAAAAAAATACCAAAGAAGAACTGGCTTTACCTCTAAAAGGA
AAAAAAAATAATTTAACAAAGAGTGATTTTCTTAAATACTTTGCCATTGAAAAATTAGGATTAAACCAGAACGTCATCGA
TGGGATCGTACAAGAGTTCCATCAGGTAATACCAAAATGGCAAGAGCTGATTGGTGTCAGTTTTTTATCTCAACCGATGC
AGGAAAAATATCTCGAATTGCTAGAGCAACGGTGCAAGCGATTAAATTTTTTTGATTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11557.38 Da        Isoelectric Point: 4.5994

>AT135117 WP_010948073.1 NZ_CP042254:3545367-3545675 [Legionella longbeachae]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT135117 NZ_CP042254:3545367-3545675 [Legionella longbeachae]
ATGAGAAAAGCATACGTATCGGTGAGTGGCATTAAGGCTGGAATATTAGAAGAATTACAAGGTGGAACCTATCAATTTAC
CTACTTTGAGGATTATCACGGCGCACCTGTTTCACTCACTATGCCGTTGAAAAATAAGGTCTATGATTTTGACGTGTTCC
CCCCTTTTTTTGAAGGATTACTTCCTGAAGGCATTATGCTTGAAGCACTATTACGCAAATACAAGATAGATAAAAATGAT
TATTTTGGTCAATTGATACTAGTTGGCCAAGATGTCGTAGGCGCAGTGACTATTGAGGAAATAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
PDB7VKB
AlphaFold DBQ5ZSZ7

References