Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2178800..2179394 Replicon chromosome
Accession NZ_CP042254
Organism Legionella longbeachae strain B3526CHC

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FQU71_RS10345 Protein ID WP_150866402.1
Coordinates 2178800..2179120 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag FQU71_RS10350 Protein ID WP_150866403.1
Coordinates 2179104..2179394 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU71_RS10325 2175264..2176088 - 825 WP_150866400.1 hypothetical protein -
FQU71_RS10330 2176172..2177191 - 1020 WP_191968178.1 site-specific integrase -
FQU71_RS10340 2177204..2178598 - 1395 WP_150866401.1 transposase -
FQU71_RS10345 2178800..2179120 + 321 WP_150866402.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FQU71_RS10350 2179104..2179394 + 291 WP_150866403.1 HigA family addiction module antidote protein Antitoxin
FQU71_RS10355 2179453..2179725 + 273 WP_012979099.1 hypothetical protein -
FQU71_RS10360 2180119..2180886 - 768 WP_150866404.1 LuxR family transcriptional regulator -
FQU71_RS10365 2181233..2181955 + 723 WP_150866405.1 hypothetical protein -
FQU71_RS10370 2182433..2182921 + 489 WP_150867581.1 cupin domain-containing protein -
FQU71_RS10375 2183050..2183952 - 903 WP_003637200.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - pilZ / pilD / pilC / pilB 1968696..2256661 287965
- flank IS/Tn - - 2177204..2178598 1394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12597.61 Da        Isoelectric Point: 9.8440

>T135116 WP_150866402.1 NZ_CP042254:2178800-2179120 [Legionella longbeachae]
MIINFQDKLTEDIFNVVSSRYSIKLPSELHKKAQRKLDMIHAATLRDTLKIPPKNKLAKLCGNLSEYWRIKIDKQWAVIF
RWENGYAYDVCISDYHDKRENNVINK

Download         Length: 321 bp

>T135116 NZ_CP042254:2178800-2179120 [Legionella longbeachae]
ATGATAATTAATTTCCAGGATAAATTGACCGAAGATATTTTTAATGTGGTAAGCAGCCGGTATTCAATAAAGCTTCCAAG
TGAATTACACAAAAAGGCACAACGAAAGTTGGATATGATTCACGCAGCAACACTTAGAGATACATTGAAAATTCCACCAA
AAAATAAACTAGCGAAGTTATGTGGCAATTTATCAGAGTATTGGCGAATTAAAATTGATAAACAATGGGCTGTCATTTTC
CGTTGGGAAAATGGATATGCTTATGATGTCTGTATCAGTGATTATCATGACAAAAGAGAAAACAATGTTATCAACAAATA
G

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 11084.95 Da        Isoelectric Point: 10.0973

>AT135116 WP_150866403.1 NZ_CP042254:2179104-2179394 [Legionella longbeachae]
MLSTNRPPTLPGEVLLERFIKPMNLTQKAFASHLGWTYAKLNEIVHGKRGITPDTALDLADALNMEPEFWLNLQRDWELW
HAKQKHKIIAKINAIK

Download         Length: 291 bp

>AT135116 NZ_CP042254:2179104-2179394 [Legionella longbeachae]
ATGTTATCAACAAATAGACCCCCTACTCTCCCAGGTGAGGTGCTTTTGGAGAGATTTATTAAACCTATGAATTTAACCCA
AAAGGCATTTGCATCCCATCTAGGCTGGACTTATGCCAAATTGAATGAAATCGTTCATGGCAAAAGAGGGATCACACCAG
ACACAGCTTTAGATTTAGCTGATGCTTTAAATATGGAGCCCGAATTTTGGCTAAATCTTCAAAGAGATTGGGAGCTCTGG
CATGCAAAACAAAAACACAAAATAATAGCAAAAATAAATGCAATTAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References