Detailed information of TA system TA135103

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4177799..4178057
• Replicon: chromosome
• Accession: NZ_CP042250
• Organism: Escherichia coli strain BCE049

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: FQU84_RS22560
• Protein ID: WP_001181672.1
• Coordinates: 4177848..4178057 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4177799..4177856 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQU84_RS22545	4173631..4174890	-	1260	WP_000494924.1	hypothetical protein	-
FQU84_RS22550	4175019..4176512	-	1494	WP_001350775.1	sulfatase-like hydrolase/transferase	-
FQU84_RS22555	4176532..4177293	-	762	WP_001274823.1	hypothetical protein	-
-	4177799..4177856	-	58	-	-	Antitoxin
FQU84_RS22560	4177848..4178057	+	210	WP_001181672.1	type I toxin-antitoxin system Hok family toxin	Toxin
FQU84_RS22565	4178162..4179292	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
FQU84_RS22570	4179381..4181297	-	1917	WP_000516135.1	molecular chaperone DnaK	-
FQU84_RS22575	4181669..4182073	+	405	WP_000843687.1	DUF2541 family protein	-
FQU84_RS22580	4182099..4182812	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7757.25 Da
• Isoelectric Point: 9.3680

>T135103 WP_001181672.1 NZ_CP042250:4177848-4178057 [Escherichia coli]
MQNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T135103 NZ_CP042250:4177848-4178057 [Escherichia coli]
ATGCAGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATGAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT135103 NZ_CP042250:c4177856-4177799 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin