Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3087736..3088238 Replicon chromosome
Accession NZ_CP042250
Organism Escherichia coli strain BCE049

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag FQU84_RS17245 Protein ID WP_089580013.1
Coordinates 3087736..3087990 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FQU84_RS17250 Protein ID WP_001259255.1
Coordinates 3087987..3088238 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQU84_RS17225 3084229..3085587 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
FQU84_RS17230 3085577..3085639 - 63 WP_010723108.1 membrane protein YoeI -
FQU84_RS17235 3085854..3086783 - 930 WP_097501769.1 LysR family transcriptional regulator -
FQU84_RS17240 3086829..3087653 - 825 WP_145768638.1 SDR family oxidoreductase -
FQU84_RS17245 3087736..3087990 - 255 WP_089580013.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FQU84_RS17250 3087987..3088238 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FQU84_RS17255 3088521..3088571 + 51 WP_001364200.1 his operon leader peptide -
FQU84_RS17260 3088717..3089616 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
FQU84_RS17265 3089622..3090926 + 1305 WP_089580014.1 histidinol dehydrogenase -
FQU84_RS17270 3090923..3091993 + 1071 WP_024249713.1 histidinol-phosphate transaminase -
FQU84_RS17275 3091993..3093060 + 1068 WP_097501770.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10153.56 Da        Isoelectric Point: 8.0353

>T135100 WP_089580013.1 NZ_CP042250:c3087990-3087736 [Escherichia coli]
VKLIWSEESWDDYLYWQEADKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T135100 NZ_CP042250:c3087990-3087736 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT135100 WP_001259255.1 NZ_CP042250:c3088238-3087987 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT135100 NZ_CP042250:c3088238-3087987 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References