Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1019623..1020212 Replicon chromosome
Accession NZ_CP042242
Organism Oxalobacter formigenes strain SSYG-15

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FPZ51_RS04575 Protein ID WP_005880108.1
Coordinates 1019934..1020212 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FPZ51_RS04570 Protein ID WP_005880107.1
Coordinates 1019623..1019922 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FPZ51_RS04550 1014952..1015341 - 390 WP_005880102.1 NirD/YgiW/YdeI family stress tolerance protein -
FPZ51_RS04555 1015737..1016747 + 1011 WP_005880103.1 ADP-glyceromanno-heptose 6-epimerase -
FPZ51_RS04560 1017007..1018086 + 1080 WP_036602709.1 porin -
FPZ51_RS04565 1018410..1019477 + 1068 WP_005880106.1 porin -
FPZ51_RS04570 1019623..1019922 - 300 WP_005880107.1 HigA family addiction module antidote protein Antitoxin
FPZ51_RS04575 1019934..1020212 - 279 WP_005880108.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FPZ51_RS04580 1020685..1021878 + 1194 WP_005880109.1 MFS transporter -
FPZ51_RS04585 1022119..1023828 + 1710 WP_086131830.1 hypothetical protein -
FPZ51_RS04590 1023893..1024711 + 819 WP_050757770.1 sel1 repeat family protein -
FPZ51_RS04595 1024870..1025085 + 216 WP_005880112.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-86)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10670.21 Da        Isoelectric Point: 9.7825

>T135020 WP_005880108.1 NZ_CP042242:c1020212-1019934 [Oxalobacter formigenes]
MIKSFTCPDTQDLFAGKTVPRFVNIRSVAERKLQMIHRATGINDLRIPPNNRLEALKGDRKGQYSIRINDQWRICFTFDN
GQAFDVSIVDYH

Download         Length: 279 bp

>T135020 NZ_CP042242:c1020212-1019934 [Oxalobacter formigenes]
ATGATTAAATCGTTCACATGTCCGGATACACAAGACCTGTTTGCCGGTAAAACCGTTCCCCGGTTTGTCAACATCCGGTC
AGTAGCGGAACGCAAACTCCAGATGATTCACAGGGCTACGGGCATAAACGATTTACGAATTCCACCCAATAACCGCCTTG
AAGCGTTAAAAGGCGATAGAAAAGGTCAATACAGCATAAGAATTAATGACCAGTGGCGCATTTGTTTCACGTTCGATAAT
GGACAGGCTTTTGATGTTTCGATTGTCGATTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11408.12 Da        Isoelectric Point: 6.4636

>AT135020 WP_005880107.1 NZ_CP042242:c1019922-1019623 [Oxalobacter formigenes]
MDNIINGMRPIHPGEILREEFLSPMNLSSNALAIELHVPAPRINEIVRERRSITADTALRLARYFGTSAEFWMGLQDDYD
LKTCQRKLDETLGRIIPRQ

Download         Length: 300 bp

>AT135020 NZ_CP042242:c1019922-1019623 [Oxalobacter formigenes]
ATGGATAACATTATTAATGGCATGAGGCCAATACATCCGGGGGAAATTCTCAGAGAAGAATTTCTGTCCCCGATGAACTT
GTCTTCCAATGCACTGGCCATTGAACTGCACGTCCCCGCGCCACGGATAAATGAAATTGTCCGTGAACGCAGAAGCATCA
CGGCAGATACCGCTTTACGTCTTGCCCGTTATTTTGGAACAAGTGCTGAATTCTGGATGGGCTTGCAAGATGATTACGAT
CTGAAAACCTGCCAGAGAAAACTCGATGAAACGCTTGGCCGGATTATTCCGCGCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References