Detailed information of TA system TA134986

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2722688..2723025
• Replicon: chromosome
• Accession: NZ_CP042216
• Organism: Enterococcus faecalis strain L8

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: FOA09_RS13075
• Protein ID: WP_016619108.1
• Coordinates: 2722688..2722831 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2722763..2723025 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOA09_RS13060	2718404..2719036	-	633	WP_002358972.1	RloB family protein	-
FOA09_RS13065	2719045..2720340	-	1296	WP_002410675.1	AAA family ATPase	-
FOA09_RS13070	2720802..2722418	+	1617	WP_153246973.1	phosphatase PAP2/LCP family protein	-
-	2722514..2722577	-	64	NuclAT_8	-	-
FOA09_RS13075	2722688..2722831	+	144	WP_016619108.1	putative holin-like toxin	Toxin
-	2722763..2723025	-	263	NuclAT_5	-	Antitoxin
-	2722975..2723024	+	50	NuclAT_9	-	-
FOA09_RS13080	2723026..2727717	-	4692	WP_153246974.1	WxL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5191.13 Da
• Isoelectric Point: 8.6626

>T134986 WP_016619108.1 NZ_CP042216:2722688-2722831 [Enterococcus faecalis]
MNVSTKTYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Nucleotide

• Length: 144 bp

>T134986 NZ_CP042216:2722688-2722831 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAACCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 263 bp

>AT134986 NZ_CP042216:c2723025-2722763 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGATCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Antitoxin