Detailed information of TA system TA134978

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2620566..2620828
• Replicon: chromosome
• Accession: NZ_CP042216
• Organism: Enterococcus faecalis strain L8

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: S4BYM2
• Locus tag: FOA09_RS12615
• Protein ID: WP_002392696.1
• Coordinates: 2620685..2620828 (-)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2620566..2620711 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOA09_RS12600	2615933..2616646	-	714	WP_002354877.1	trehalose operon repressor	-
FOA09_RS12605	2616908..2619652	+	2745	WP_153246966.1	glycoside hydrolase family 65 protein	-
FOA09_RS12610	2619667..2620317	+	651	WP_002367457.1	beta-phosphoglucomutase	-
-	2620386..2620519	+	134	NuclAT_7	-	-
-	2620566..2620711	+	146	NuclAT_6	-	Antitoxin
-	2620566..2620752	+	187	NuclAT_10	-	-
FOA09_RS12615	2620685..2620828	-	144	WP_002392696.1	putative holin-like toxin	Toxin
FOA09_RS12620	2621578..2621772	+	195	Protein_2458	CPBP family intramembrane metalloprotease	-
FOA09_RS12625	2621826..2622797	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
FOA09_RS12630	2622972..2623409	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
FOA09_RS12635	2623542..2624096	-	555	WP_002378827.1	septum formation protein Maf	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5297.43 Da
• Isoelectric Point: 10.6867

>T134978 WP_002392696.1 NZ_CP042216:c2620828-2620685 [Enterococcus faecalis]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 144 bp

>T134978 NZ_CP042216:c2620828-2620685 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACGGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 146 bp

>AT134978 NZ_CP042216:2620566-2620711 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAA

Structures

Toxin

• AlphaFold DB: S4BYM2

Antitoxin