134972

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4896697..4897283 Replicon chromosome
Accession NZ_CP042180
Organism Pseudomonas sp. KBS0802

Toxin (Protein)


Gene name graT Uniprot ID Q88MI5
Locus tag FFH79_RS23040 Protein ID WP_010952670.1
Coordinates 4896697..4896975 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID Q88MI6
Locus tag FFH79_RS23045 Protein ID WP_010952669.1
Coordinates 4896984..4897283 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFH79_RS23025 4893498..4894694 + 1197 WP_010952672.1 succinyldiaminopimelate transaminase -
FFH79_RS23035 4894800..4896446 - 1647 WP_049587427.1 Na+/H+ antiporter -
FFH79_RS23040 4896697..4896975 + 279 WP_010952670.1 type II toxin-antitoxin system toxin GraT Toxin
FFH79_RS23045 4896984..4897283 + 300 WP_010952669.1 type II toxin-antitoxin system antitoxin GraA Antitoxin
FFH79_RS23050 4897575..4897877 - 303 WP_049587425.1 hypothetical protein -
FFH79_RS23055 4897943..4898443 - 501 WP_010952668.1 DUF2514 domain-containing protein -
FFH79_RS23060 4898440..4898883 - 444 WP_049587424.1 structural protein P5 -
FFH79_RS23065 4898944..4900020 - 1077 WP_010952666.1 hypothetical protein -
FFH79_RS23070 4900032..4902023 - 1992 WP_010952665.1 glycoside hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10446.72 Da        Isoelectric Point: 7.2450

>T134972 WP_010952670.1 NZ_CP042180:4896697-4896975 [Pseudomonas sp. KBS0802]
MIRSFSCADTEALFTTGKTRRGSDIKSVAERKLAMLDAATELRDLRSPPGNRLESLSGNRADQHSIRVNDQWRLCFTWTE
HGPVNVEIVDYH

Download         Length: 279 bp

>T134972 NZ_CP042180:4896697-4896975 [Pseudomonas sp. KBS0802]
ATGATTCGAAGCTTTAGCTGTGCCGACACGGAAGCGCTCTTCACAACGGGAAAGACACGGCGCGGGTCAGATATCAAGTC
AGTCGCGGAGCGCAAGCTGGCCATGCTCGATGCCGCAACAGAGTTGCGAGACCTTAGGTCGCCACCTGGCAATCGCCTCG
AGTCACTGAGCGGCAACCGCGCCGACCAGCACAGTATCCGTGTAAATGACCAATGGCGGTTGTGCTTCACCTGGACAGAG
CACGGGCCAGTTAACGTTGAAATTGTCGATTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10905.55 Da        Isoelectric Point: 5.6793

>AT134972 WP_010952669.1 NZ_CP042180:4896984-4897283 [Pseudomonas sp. KBS0802]
MLKNGMRPIHPGEILREEFQKEMGFSAAALARALGVATPTVNNILRERGGVSADMALRLSICLDTTPEFWLNLQTAFDLR
TAEQQHGDEIIGSVQRLVA

Download         Length: 300 bp

>AT134972 NZ_CP042180:4896984-4897283 [Pseudomonas sp. KBS0802]
ATGCTCAAGAACGGTATGCGTCCAATCCATCCGGGTGAAATCCTGCGGGAGGAGTTCCAGAAGGAAATGGGCTTCAGCGC
CGCGGCTCTGGCCAGGGCGTTGGGTGTAGCAACGCCAACCGTCAACAACATCCTGCGCGAACGGGGCGGTGTTTCCGCCG
ACATGGCACTGCGCCTGTCCATCTGCCTGGACACCACCCCTGAGTTCTGGCTCAACCTGCAGACGGCCTTCGATCTGCGC
ACAGCCGAACAGCAACACGGCGATGAGATCATCGGGTCGGTCCAGCGTCTGGTCGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6F8S

Antitoxin

Source ID Structure
AlphaFold DB Q88MI6

References