Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2625887..2626502 Replicon chromosome
Accession NZ_CP042178
Organism Burkholderia sp. KBS0801

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FFI87_RS28645 Protein ID WP_138849858.1
Coordinates 2625887..2626228 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FFI87_RS28650 Protein ID WP_138849857.1
Coordinates 2626215..2626502 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FFI87_RS28635 2622972..2624609 - 1638 WP_138850258.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -
FFI87_RS28640 2625039..2625671 + 633 WP_138849859.1 LysE family translocator -
FFI87_RS28645 2625887..2626228 + 342 WP_138849858.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FFI87_RS28650 2626215..2626502 + 288 WP_138849857.1 helix-turn-helix transcriptional regulator Antitoxin
FFI87_RS28655 2626626..2627195 - 570 WP_006749371.1 hypothetical protein -
FFI87_RS28660 2627416..2627874 - 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
FFI87_RS28665 2628000..2628737 + 738 WP_138849856.1 AzlC family ABC transporter permease -
FFI87_RS28670 2628730..2629029 + 300 WP_138850257.1 AzlD family protein -
FFI87_RS28675 2629224..2630003 + 780 WP_138849855.1 5'/3'-nucleotidase SurE -
FFI87_RS28680 2630109..2630930 - 822 WP_138849854.1 SDR family oxidoreductase -
FFI87_RS28685 2631000..2631467 - 468 WP_138849853.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13153.39 Da        Isoelectric Point: 10.1617

>T134964 WP_138849858.1 NZ_CP042178:2625887-2626228 [Burkholderia sp. KBS0801]
MRTVAYEIHFFSEQVEAGVFALPKTLTARFFALADRMEQYGPNLGEPHTRPMGDGLYEMRLKGLEGIARVFYCAAVDRRI
VMLHCFVKKTQKTPRKELETARRRLKEIRYGNL

Download         Length: 342 bp

>T134964 NZ_CP042178:2625887-2626228 [Burkholderia sp. KBS0801]
ATGCGAACCGTCGCGTATGAAATCCATTTCTTCAGCGAGCAAGTCGAGGCAGGCGTGTTTGCGTTGCCGAAGACGCTGAC
CGCCAGGTTCTTCGCACTCGCTGACCGTATGGAGCAGTACGGCCCGAATCTGGGCGAACCTCACACCAGGCCGATGGGCG
ACGGGTTGTATGAAATGCGCTTGAAGGGCCTGGAAGGTATCGCCCGTGTGTTTTACTGTGCGGCCGTCGACCGGCGGATC
GTCATGCTTCACTGCTTCGTGAAGAAGACGCAGAAAACGCCGCGAAAAGAACTGGAAACCGCGCGCCGCCGATTGAAGGA
GATTCGATATGGCAACCTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10393.02 Da        Isoelectric Point: 10.4476

>AT134964 WP_138849857.1 NZ_CP042178:2626215-2626502 [Burkholderia sp. KBS0801]
MATYKALRERALSDPKVRAEYDRLNREEFALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIDTLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT134964 NZ_CP042178:2626215-2626502 [Burkholderia sp. KBS0801]
ATGGCAACCTATAAGGCACTGCGCGAGCGCGCGTTGTCCGATCCGAAGGTACGCGCCGAATACGACCGGCTGAACCGCGA
GGAATTCGCGCTGCTCGACGCAATGCTGGCCGCCCGGCGAGCCGCCGGTCTTTCGCAGGCCGATGTGGCAGAGCGCATGG
GCACGAAGGCGCCTGCCGTCACGCGGCTCGAACGCGCGCTCGCGACAGGCCAGCACTCTCCATCGATCGACACGCTGCGC
AAGTATGCGGCTGCTTGCGGAAAGAAACTCGTGATCTCTTTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References