Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1151580..1152174 Replicon chromosome
Accession NZ_CP042170
Organism Flavobacterium sp. KBS0721

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag B0M43_RS05190 Protein ID WP_078006600.1
Coordinates 1151893..1152174 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag B0M43_RS05185 Protein ID WP_078006978.1
Coordinates 1151580..1151882 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
B0M43_RS05165 1147221..1148408 - 1188 WP_078006604.1 glycosyltransferase family 4 protein -
B0M43_RS05170 1148408..1149496 - 1089 WP_078006603.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
B0M43_RS05175 1149701..1150228 - 528 WP_078006602.1 ORF6N domain-containing protein -
B0M43_RS05180 1150270..1151580 - 1311 WP_078006601.1 phenylacetate--CoA ligase family protein -
B0M43_RS05185 1151580..1151882 - 303 WP_078006978.1 HigA family addiction module antidote protein Antitoxin
B0M43_RS05190 1151893..1152174 - 282 WP_078006600.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
B0M43_RS05195 1152270..1153544 + 1275 WP_078006599.1 phosphoribosylamine--glycine ligase -
B0M43_RS05205 1153908..1154837 + 930 WP_065451772.1 hypothetical protein -
B0M43_RS05210 1154832..1155485 - 654 WP_078006598.1 uracil phosphoribosyltransferase -
B0M43_RS05215 1155597..1156202 + 606 WP_065452014.1 DUF4254 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-64)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10960.71 Da        Isoelectric Point: 10.5348

>T134932 WP_078006600.1 NZ_CP042170:c1152174-1151893 [Flavobacterium sp. KBS0721]
MIISFGSKETEKIWNGIVVKKPSIEIQQIGRRKLRMLHNSQNLTDLRIPPSNRLEKLAGNLKDFYSIRINNQWRIIFVWE
NGNALNVEIVDYH

Download         Length: 282 bp

>T134932 NZ_CP042170:c1152174-1151893 [Flavobacterium sp. KBS0721]
ATGATAATCTCATTTGGATCTAAAGAAACTGAAAAAATTTGGAATGGTATTGTGGTCAAAAAACCTTCGATTGAGATACA
GCAAATTGGCAGAAGAAAACTCAGAATGCTGCATAACTCTCAAAATTTAACCGATTTGAGAATTCCGCCTTCTAATCGTT
TAGAAAAATTAGCAGGTAACTTAAAAGATTTTTATAGCATTCGAATTAACAATCAATGGCGAATAATTTTTGTTTGGGAA
AATGGAAATGCATTAAATGTAGAAATTGTTGATTATCATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11689.39 Da        Isoelectric Point: 5.7683

>AT134932 WP_078006978.1 NZ_CP042170:c1151882-1151580 [Flavobacterium sp. KBS0721]
MEKLKNIHPGEILSEEFLIPLNITPYRLSKDLKIPQTRISEIIKGNRRITADTALRLSHYFGNSAKFWLGLQDDFDIEEE
ESNKSDELKLIKRYDLKEAV

Download         Length: 303 bp

>AT134932 NZ_CP042170:c1151882-1151580 [Flavobacterium sp. KBS0721]
ATGGAAAAATTAAAAAACATACATCCAGGAGAAATTTTATCGGAAGAATTTTTAATTCCGCTAAATATTACACCTTATCG
TTTATCTAAAGATTTAAAAATTCCGCAAACCAGAATTTCTGAAATCATTAAGGGAAACCGCAGAATTACTGCTGATACCG
CTTTGCGACTAAGTCATTATTTTGGAAATTCGGCTAAATTTTGGTTGGGACTTCAGGACGATTTTGATATTGAAGAAGAG
GAATCAAATAAAAGCGACGAACTAAAATTGATTAAACGTTACGATTTAAAAGAAGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References