Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/MazF-doc |
Location | 5806..6410 | Replicon | plasmid pSALNC17 |
Accession | NZ_CP042158 | ||
Organism | Staphylococcus aureus strain B3-17D |
Toxin (Protein)
Gene name | pemK | Uniprot ID | L7PFJ6 |
Locus tag | FP481_RS14520 | Protein ID | WP_001022435.1 |
Coordinates | 5806..6144 (-) | Length | 113 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | L7PH55 |
Locus tag | FP481_RS14525 | Protein ID | WP_001129937.1 |
Coordinates | 6141..6410 (-) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FP481_RS14495 | 1575..2858 | + | 1284 | WP_000083517.1 | replication initiator protein A | - |
FP481_RS14500 | 2890..3123 | + | 234 | WP_001002995.1 | hypothetical protein | - |
FP481_RS14505 | 3133..3543 | + | 411 | WP_114306678.1 | hypothetical protein | - |
FP481_RS14510 | 3695..4369 | - | 675 | WP_001106066.1 | IS6 family transposase | - |
FP481_RS14515 | 4948..5631 | - | 684 | WP_000277644.1 | CPBP family intramembrane metalloprotease | - |
FP481_RS14520 | 5806..6144 | - | 339 | WP_001022435.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
FP481_RS14525 | 6141..6410 | - | 270 | WP_001129937.1 | hypothetical protein | Antitoxin |
FP481_RS14530 | 6981..7790 | + | 810 | WP_001106667.1 | alpha/beta hydrolase | - |
FP481_RS14535 | 7903..8634 | + | 732 | WP_000753929.1 | CPBP family intramembrane metalloprotease | - |
FP481_RS14540 | 8938..9306 | - | 369 | WP_041203784.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Non-Mobilizable plasmid | - | - | 1..17383 | 17383 | ||
- | flank | IS/Tn | - | - | 3695..4369 | 674 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 113 a.a. Molecular weight: 13001.20 Da Isoelectric Point: 10.1988
>T134918 WP_001022435.1 NZ_CP042158:c6144-5806 [Staphylococcus aureus]
MNIKQFDILYIDLNPTRGREKHNVRPCLVINNQMSIDGTNFVWVLPITTRGLRYPTDIQLKTKKGLVSGVIDTVQIRALD
LKARQYNYKDELQDNLKNDILKAIKTYLKPTL
MNIKQFDILYIDLNPTRGREKHNVRPCLVINNQMSIDGTNFVWVLPITTRGLRYPTDIQLKTKKGLVSGVIDTVQIRALD
LKARQYNYKDELQDNLKNDILKAIKTYLKPTL
Download Length: 339 bp
>T134918 NZ_CP042158:c6144-5806 [Staphylococcus aureus]
ATGAACATTAAACAATTTGACATACTCTACATTGATTTAAATCCAACTCGTGGACGTGAAAAGCATAACGTAAGGCCCTG
CTTAGTGATAAATAATCAGATGAGTATTGATGGCACTAATTTTGTTTGGGTTTTACCCATAACAACTCGGGGTTTACGTT
ATCCAACAGATATCCAACTTAAAACAAAAAAAGGATTAGTATCTGGTGTGATAGACACTGTTCAAATACGCGCTTTAGAC
CTAAAAGCACGTCAATACAACTATAAAGACGAACTACAGGACAATTTAAAAAATGATATATTAAAAGCGATAAAAACTTA
TCTTAAGCCAACGTTATAA
ATGAACATTAAACAATTTGACATACTCTACATTGATTTAAATCCAACTCGTGGACGTGAAAAGCATAACGTAAGGCCCTG
CTTAGTGATAAATAATCAGATGAGTATTGATGGCACTAATTTTGTTTGGGTTTTACCCATAACAACTCGGGGTTTACGTT
ATCCAACAGATATCCAACTTAAAACAAAAAAAGGATTAGTATCTGGTGTGATAGACACTGTTCAAATACGCGCTTTAGAC
CTAAAAGCACGTCAATACAACTATAAAGACGAACTACAGGACAATTTAAAAAATGATATATTAAAAGCGATAAAAACTTA
TCTTAAGCCAACGTTATAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10185.65 Da Isoelectric Point: 10.1641
>AT134918 WP_001129937.1 NZ_CP042158:c6410-6141 [Staphylococcus aureus]
MAKSLKDLNKTSERVFKNGNSKAISLSKKTIRLANFDIGDTVEVQKMNGGLFITKKKESIEDRIKNFFQSGGKYTELEVD
WEERVGREI
MAKSLKDLNKTSERVFKNGNSKAISLSKKTIRLANFDIGDTVEVQKMNGGLFITKKKESIEDRIKNFFQSGGKYTELEVD
WEERVGREI
Download Length: 270 bp
>AT134918 NZ_CP042158:c6410-6141 [Staphylococcus aureus]
ATGGCTAAATCATTAAAAGACTTAAACAAGACTTCGGAACGAGTTTTTAAAAATGGAAACAGTAAAGCAATCAGTTTAAG
TAAAAAAACTATCAGGTTAGCTAATTTTGATATAGGAGATACAGTTGAAGTTCAAAAAATGAATGGTGGTTTGTTCATTA
CTAAAAAAAAGGAGTCTATTGAAGATAGAATTAAAAATTTCTTTCAAAGTGGTGGAAAGTATACAGAATTAGAAGTAGAT
TGGGAAGAAAGAGTTGGCCGAGAAATATGA
ATGGCTAAATCATTAAAAGACTTAAACAAGACTTCGGAACGAGTTTTTAAAAATGGAAACAGTAAAGCAATCAGTTTAAG
TAAAAAAACTATCAGGTTAGCTAATTTTGATATAGGAGATACAGTTGAAGTTCAAAAAATGAATGGTGGTTTGTTCATTA
CTAAAAAAAAGGAGTCTATTGAAGATAGAATTAAAAATTTCTTTCAAAGTGGTGGAAAGTATACAGAATTAGAAGTAGAT
TGGGAAGAAAGAGTTGGCCGAGAAATATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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