Detailed information of TA system TA134903

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 34148..34623
• Replicon: chromosome
• Accession: NZ_CP042157
• Organism: Staphylococcus aureus strain B3-17D

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: FP481_RS00195
• Protein ID: WP_000387655.1
• Coordinates: 34148..34450 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	34499..34623 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP481_RS00180	29968..30921	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
FP481_RS00185	31598..32338	-	741	WP_000185611.1	CPBP family intramembrane metalloprotease	-
FP481_RS00190	32683..34137	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
FP481_RS00195	34148..34450	-	303	WP_000387655.1	phage holin	Toxin
-	34499..34623	+	125	-	-	Antitoxin
FP481_RS00200	34501..34608	+	108	Protein_39	hypothetical protein	-
-	34530..34623	+	94	NuclAT_0	-	-
-	34530..34623	+	94	NuclAT_0	-	-
-	34530..34623	+	94	NuclAT_0	-	-
-	34530..34623	+	94	NuclAT_0	-	-
FP481_RS00205	34648..34795	-	148	Protein_40	putative holin-like toxin	-
FP481_RS00210	34989..35288	-	300	WP_000466781.1	DUF2951 family protein	-
FP481_RS00215	35334..35498	-	165	WP_000916020.1	XkdX family protein	-
FP481_RS00220	35491..35880	-	390	WP_001166602.1	DUF2977 domain-containing protein	-
FP481_RS00225	35880..37346	-	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
FP481_RS00230	37346..39256	-	1911	WP_000429548.1	hypothetical protein	-
FP481_RS00235	39272..39562	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	32683..84952	52269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T134903 WP_000387655.1 NZ_CP042157:c34450-34148 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T134903 NZ_CP042157:c34450-34148 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATAACAAGATATATTGTATTAATTTTAGCATTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCTGAAAGTAAATATAGAAAAGCAACAGGT
CAAGCACCTGTCAAAGAAGTAATAGCACCTACAAATATGAACGATACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 125 bp

>AT134903 NZ_CP042157:34499-34623 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin