Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2536828..2537012 Replicon chromosome
Accession NZ_CP042153
Organism Staphylococcus aureus strain B4-59C

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag FP482_RS12810 Protein ID WP_000482652.1
Coordinates 2536905..2537012 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2536828..2536888 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP482_RS12795 2532283..2532450 - 168 Protein_2426 hypothetical protein -
FP482_RS12800 2532681..2534414 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
FP482_RS12805 2534439..2536202 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 2536828..2536888 + 61 - - Antitoxin
FP482_RS12810 2536905..2537012 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
FP482_RS12815 2537146..2537532 - 387 WP_000779360.1 flippase GtxA -
FP482_RS12820 2537800..2538942 + 1143 WP_001176863.1 glycerate kinase -
FP482_RS12825 2539002..2539661 + 660 WP_000831298.1 membrane protein -
FP482_RS12830 2539843..2541054 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
FP482_RS12835 2541177..2541650 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.



Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T134899 WP_000482652.1 NZ_CP042153:c2537012-2536905 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T134899 NZ_CP042153:c2537012-2536905 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT134899 NZ_CP042153:2536828-2536888 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5


Antitoxin

Download structure file

References