Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2511470..2511987 Replicon chromosome
Accession NZ_CP042153
Organism Staphylococcus aureus strain B4-59C

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag FP482_RS12670 Protein ID WP_000113265.1
Coordinates 2511470..2511736 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag FP482_RS12675 Protein ID WP_000584499.1
Coordinates 2511736..2511987 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP482_RS12640 2506898..2507434 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
FP482_RS12645 2507668..2508492 - 825 WP_000572038.1 formate/nitrite transporter family protein -
FP482_RS12650 2508709..2508891 - 183 WP_000230292.1 hypothetical protein -
FP482_RS12655 2508975..2509442 - 468 WP_000153347.1 SRPBCC domain-containing protein -
FP482_RS12660 2509628..2511175 - 1548 WP_000727774.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FP482_RS12665 2511364..2511435 - 72 Protein_2401 hypothetical protein -
FP482_RS12670 2511470..2511736 - 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
FP482_RS12675 2511736..2511987 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FP482_RS12680 2512152..2512253 - 102 Protein_2404 hypothetical protein -
FP482_RS12685 2512260..2512859 - 600 WP_000162810.1 DsbA family protein -
FP482_RS12690 2512878..2513240 - 363 WP_000819843.1 DUF4467 domain-containing protein -
FP482_RS12695 2513495..2514745 + 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
FP482_RS12700 2514842..2515573 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
FP482_RS12705 2515570..2516289 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T134898 WP_000113265.1 NZ_CP042153:c2511736-2511470 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T134898 NZ_CP042153:c2511736-2511470 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT134898 WP_000584499.1 NZ_CP042153:c2511987-2511736 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT134898 NZ_CP042153:c2511987-2511736 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BWF

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References