Detailed information of TA system TA134891

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2073729..2074204
• Replicon: chromosome
• Accession: NZ_CP042153
• Organism: Staphylococcus aureus strain B4-59C

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: FP482_RS10295
• Protein ID: WP_000387655.1
• Coordinates: 2073729..2074031 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2074080..2074204 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP482_RS10280	2069549..2070502	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
FP482_RS10285	2071179..2071919	-	741	WP_000185611.1	CPBP family intramembrane metalloprotease	-
FP482_RS10290	2072264..2073718	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
FP482_RS10295	2073729..2074031	-	303	WP_000387655.1	phage holin	Toxin
-	2074080..2074204	+	125	-	-	Antitoxin
FP482_RS10305	2074229..2074376	-	148	Protein_1952	putative holin-like toxin	-
FP482_RS10310	2074570..2074869	-	300	WP_000466781.1	DUF2951 family protein	-
FP482_RS10315	2074915..2075079	-	165	WP_000916020.1	XkdX family protein	-
FP482_RS10320	2075072..2075461	-	390	WP_001166602.1	DUF2977 domain-containing protein	-
FP482_RS10325	2075461..2076927	-	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
FP482_RS10330	2076927..2078837	-	1911	WP_000429548.1	hypothetical protein	-
FP482_RS10335	2078853..2079143	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2072264..2124533	52269

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T134891 WP_000387655.1 NZ_CP042153:c2074031-2073729 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T134891 NZ_CP042153:c2074031-2073729 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATAACAAGATATATTGTATTAATTTTAGCATTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCTGAAAGTAAATATAGAAAAGCAACAGGT
CAAGCACCTGTCAAAGAAGTAATAGCACCTACAAATATGAACGATACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 125 bp

>AT134891 NZ_CP042153:2074080-2074204 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin