Detailed information of TA system TA134879

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2603138..2603613
• Replicon: chromosome
• Accession: NZ_CP042107
• Organism: Staphylococcus aureus strain B8-13D

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: FP484_RS13140
• Protein ID: WP_000387655.1
• Coordinates: 2603138..2603440 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2603489..2603613 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP484_RS13125	2598958..2599911	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
FP484_RS13130	2600588..2601328	-	741	WP_000185611.1	CPBP family intramembrane metalloprotease	-
FP484_RS13135	2601673..2603127	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
FP484_RS13140	2603138..2603440	-	303	WP_000387655.1	phage holin	Toxin
-	2603489..2603613	+	125	-	-	Antitoxin
FP484_RS13150	2603638..2603785	-	148	Protein_2510	putative holin-like toxin	-
FP484_RS13155	2603979..2604278	-	300	WP_000466781.1	DUF2951 family protein	-
FP484_RS13160	2604324..2604488	-	165	WP_000916020.1	XkdX family protein	-
FP484_RS13165	2604481..2604870	-	390	WP_001166602.1	DUF2977 domain-containing protein	-
FP484_RS13170	2604870..2606336	-	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
FP484_RS13175	2606336..2608246	-	1911	WP_000429548.1	hypothetical protein	-
FP484_RS13180	2608262..2608552	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2601673..2656967	55294

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T134879 WP_000387655.1 NZ_CP042107:c2603440-2603138 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T134879 NZ_CP042107:c2603440-2603138 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATAACAAGATATATTGTATTAATTTTAGCATTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCTGAAAGTAAATATAGAAAAGCAACAGGT
CAAGCACCTGTCAAAGAAGTAATAGCACCTACAAATATGAACGATACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 125 bp

>AT134879 NZ_CP042107:2603489-2603613 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin