Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 632880..633403 Replicon chromosome
Accession NZ_CP042046
Organism Staphylococcus aureus strain B2-7A

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0E1VXK4
Locus tag FP477_RS03495 Protein ID WP_000074045.1
Coordinates 632880..633146 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0E1VMY7
Locus tag FP477_RS03500 Protein ID WP_000587619.1
Coordinates 633146..633403 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP477_RS03475 628188..629375 - 1188 WP_000026194.1 MFS transporter -
FP477_RS03480 629771..630547 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
FP477_RS03485 630540..631202 - 663 WP_000923525.1 ATP-binding cassette domain-containing protein -
FP477_RS03490 631450..632526 - 1077 WP_001076671.1 M42 family metallopeptidase -
FP477_RS03495 632880..633146 - 267 WP_000074045.1 Txe/YoeB family addiction module toxin Toxin
FP477_RS03500 633146..633403 - 258 WP_000587619.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FP477_RS03510 633763..634218 + 456 WP_000732079.1 DUF1307 domain-containing protein -
FP477_RS03515 634386..635963 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
FP477_RS03520 636159..636908 + 750 WP_000072465.1 hypothetical protein -
FP477_RS03525 637132..638325 - 1194 WP_000675407.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.36 Da        Isoelectric Point: 10.2519

>T134869 WP_000074045.1 NZ_CP042046:c633146-632880 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHPYLKKTFIEIVETLKNDPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Download         Length: 267 bp

>T134869 NZ_CP042046:c633146-632880 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATGATCCTTATAAAATAACACAATCCTTTGAAAAACTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9735.76 Da        Isoelectric Point: 4.1958

>AT134869 WP_000587619.1 NZ_CP042046:c633403-633146 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT134869 NZ_CP042046:c633403-633146 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1VXK4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1VMY7

References