Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 601322..601506 Replicon chromosome
Accession NZ_CP042046
Organism Staphylococcus aureus strain B2-7A

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag FP477_RS03350 Protein ID WP_000482652.1
Coordinates 601399..601506 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 601322..601382 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP477_RS03335 596777..596944 - 168 WP_145377416.1 hypothetical protein -
FP477_RS03340 597175..598908 - 1734 WP_000486499.1 ABC transporter ATP-binding protein/permease -
FP477_RS03345 598933..600696 - 1764 WP_001064837.1 ABC transporter ATP-binding protein/permease -
- 601322..601382 + 61 - - Antitoxin
FP477_RS03350 601399..601506 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
FP477_RS03355 601640..602026 - 387 WP_000779357.1 flippase GtxA -
FP477_RS03360 602294..603436 + 1143 WP_001176863.1 glycerate kinase -
FP477_RS03365 603496..604155 + 660 WP_000831298.1 membrane protein -
FP477_RS03370 604337..605548 + 1212 WP_001191922.1 multidrug effflux MFS transporter -
FP477_RS03375 605671..606144 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T134867 WP_000482652.1 NZ_CP042046:c601506-601399 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T134867 NZ_CP042046:c601506-601399 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT134867 NZ_CP042046:601322-601382 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References