Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 576015..576532 Replicon chromosome
Accession NZ_CP042046
Organism Staphylococcus aureus strain B2-7A

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag FP477_RS03210 Protein ID WP_000113262.1
Coordinates 576015..576281 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag FP477_RS03215 Protein ID WP_000584499.1
Coordinates 576281..576532 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP477_RS03180 571435..571971 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
FP477_RS03185 572205..573029 - 825 WP_000594629.1 formate/nitrite transporter family protein -
FP477_RS03190 573245..573430 - 186 WP_000230293.1 hypothetical protein -
FP477_RS03195 573514..573981 - 468 WP_000153344.1 SRPBCC domain-containing protein -
FP477_RS03200 574167..575720 - 1554 WP_000727769.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FP477_RS03205 575909..575980 - 72 Protein_581 hypothetical protein -
FP477_RS03210 576015..576281 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
FP477_RS03215 576281..576532 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FP477_RS03220 576697..576798 - 102 Protein_584 hypothetical protein -
FP477_RS03225 576805..577404 - 600 WP_000162810.1 DsbA family protein -
FP477_RS03230 577423..577785 - 363 WP_000819840.1 DUF4467 domain-containing protein -
FP477_RS03235 578040..579290 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
FP477_RS03240 579387..580118 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
FP477_RS03245 580115..580834 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T134866 WP_000113262.1 NZ_CP042046:c576281-576015 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T134866 NZ_CP042046:c576281-576015 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT134866 WP_000584499.1 NZ_CP042046:c576532-576281 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT134866 NZ_CP042046:c576532-576281 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References