Detailed information of TA system TA134857

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2705332..2705849
• Replicon: chromosome
• Accession: NZ_CP042043
• Organism: Staphylococcus aureus strain B2-15A

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: FP478_RS13725
• Protein ID: WP_000113265.1
• Coordinates: 2705332..2705598 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: FP478_RS13730
• Protein ID: WP_000584499.1
• Coordinates: 2705598..2705849 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP478_RS13695	2700760..2701296	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
FP478_RS13700	2701530..2702354	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
FP478_RS13705	2702571..2702753	-	183	WP_000230292.1	hypothetical protein	-
FP478_RS13710	2702837..2703304	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
FP478_RS13715	2703490..2705037	-	1548	WP_000727774.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
FP478_RS13720	2705226..2705297	-	72	Protein_2605	hypothetical protein	-
FP478_RS13725	2705332..2705598	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
FP478_RS13730	2705598..2705849	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FP478_RS13735	2706014..2706115	-	102	Protein_2608	hypothetical protein	-
FP478_RS13740	2706122..2706721	-	600	WP_000162810.1	DsbA family protein	-
FP478_RS13745	2706740..2707102	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
FP478_RS13750	2707357..2708607	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
FP478_RS13755	2708704..2709435	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
FP478_RS13760	2709432..2710151	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T134857 WP_000113265.1 NZ_CP042043:c2705598-2705332 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T134857 NZ_CP042043:c2705598-2705332 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT134857 WP_000584499.1 NZ_CP042043:c2705849-2705598 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT134857 NZ_CP042043:c2705849-2705598 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60