Detailed information of TA system TA134850

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2268926..2269401
• Replicon: chromosome
• Accession: NZ_CP042043
• Organism: Staphylococcus aureus strain B2-15A

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: FP478_RS11350
• Protein ID: WP_000387655.1
• Coordinates: 2268926..2269228 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2269277..2269401 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP478_RS11335	2264746..2265699	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
FP478_RS11340	2266376..2267116	-	741	WP_000185611.1	CPBP family intramembrane metalloprotease	-
FP478_RS11345	2267461..2268915	-	1455	WP_000930251.1	N-acetylmuramoyl-L-alanine amidase	-
FP478_RS11350	2268926..2269228	-	303	WP_000387655.1	phage holin	Toxin
-	2269277..2269401	+	125	-	-	Antitoxin
FP478_RS11360	2269426..2269573	-	148	Protein_2159	putative holin-like toxin	-
FP478_RS11365	2269767..2270066	-	300	WP_000466781.1	DUF2951 family protein	-
FP478_RS11370	2270112..2270276	-	165	WP_000916020.1	XkdX family protein	-
FP478_RS11375	2270269..2270658	-	390	WP_001166602.1	DUF2977 domain-containing protein	-
FP478_RS11380	2270658..2272124	-	1467	WP_000067150.1	BppU family phage baseplate upper protein	-
FP478_RS11385	2272124..2274034	-	1911	WP_000429548.1	hypothetical protein	-
FP478_RS11390	2274050..2274340	-	291	WP_000179860.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / groEL	2266376..2319730	53354

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T134850 WP_000387655.1 NZ_CP042043:c2269228-2268926 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T134850 NZ_CP042043:c2269228-2268926 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATAACAAGATATATTGTATTAATTTTAGCATTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCTGAAAGTAAATATAGAAAAGCAACAGGT
CAAGCACCTGTCAAAGAAGTAATAGCACCTACAAATATGAACGATACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 125 bp

>AT134850 NZ_CP042043:2269277-2269401 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin