Detailed information of TA system TA134847

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2101882..2102062
• Replicon: chromosome
• Accession: NZ_CP042043
• Organism: Staphylococcus aureus strain B2-15A

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: FP478_RS10300
• Protein ID: WP_001801861.1
• Coordinates: 2101882..2101977 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2102005..2102062 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FP478_RS10270	2097045..2097695	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
FP478_RS10275	2097776..2098771	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
FP478_RS10280	2098846..2099472	+	627	WP_000669024.1	hypothetical protein	-
FP478_RS10285	2099513..2099854	+	342	WP_000627540.1	DUF3969 family protein	-
FP478_RS10290	2099955..2100527	+	573	WP_000414216.1	hypothetical protein	-
FP478_RS10295	2100725..2101737	-	1013	Protein_1989	IS3 family transposase	-
FP478_RS10300	2101882..2101977	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2102005..2102062	-	58	-	-	Antitoxin
FP478_RS10305	2102100..2102201	+	102	WP_001792025.1	hypothetical protein	-
FP478_RS10310	2102179..2102340	-	162	Protein_1992	transposase	-
FP478_RS10315	2102331..2102825	-	495	Protein_1993	transposase	-
FP478_RS10320	2103277..2104506	-	1230	WP_000072627.1	restriction endonuclease subunit S	-
FP478_RS10325	2104499..2106055	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
FP478_RS10330	2106219..2106353	-	135	WP_001791797.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	2096287..2148294	52007

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T134847 WP_001801861.1 NZ_CP042043:2101882-2101977 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T134847 NZ_CP042043:2101882-2101977 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT134847 NZ_CP042043:c2102062-2102005 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin