Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 7632..8155 Replicon plasmid pSALNT46
Accession NZ_CP042004
Organism Staphylococcus aureus strain B3-14B

Toxin (Protein)


Gene name yoeB Uniprot ID A0A499S343
Locus tag FP480_RS14450 Protein ID WP_031838146.1
Coordinates 7889..8155 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A499S3X3
Locus tag FP480_RS14445 Protein ID WP_031838145.1
Coordinates 7632..7889 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FP480_RS14420 3156..3587 + 432 WP_031838157.1 hypothetical protein -
FP480_RS14425 4298..4752 + 455 Protein_7 hypothetical protein -
FP480_RS14430 4805..5479 + 675 WP_031901511.1 IS6 family transposase -
FP480_RS14435 5765..6772 - 1008 WP_031900886.1 hypothetical protein -
FP480_RS14440 6765..7484 - 720 WP_031838144.1 hypothetical protein -
FP480_RS14445 7632..7889 + 258 WP_031838145.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FP480_RS14450 7889..8155 + 267 WP_031838146.1 Txe/YoeB family addiction module toxin Toxin
FP480_RS14455 8263..8967 - 705 Protein_13 type IA DNA topoisomerase -
FP480_RS14460 8991..9665 - 675 WP_000981856.1 hypothetical protein -
FP480_RS14465 9684..11009 - 1326 WP_031838148.1 ImmA/IrrE family metallo-endopeptidase -
FP480_RS14470 11006..11569 - 564 WP_001631997.1 hypothetical protein -
FP480_RS14475 11572..11958 - 387 WP_000036315.1 hypothetical protein -
FP480_RS14480 11968..13116 - 1149 WP_001631996.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaZ - 1..46487 46487
- flank IS/Tn - - 4805..5479 674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10517.03 Da        Isoelectric Point: 10.2491

>T134845 WP_031838146.1 NZ_CP042004:7889-8155 [Staphylococcus aureus]
MNQYTVKIKNSAKSDLKKLKRSHLKEQFIEIMETLKSNPYEASQSFEKLEPKNLKRYSRRINHQHRVVYTVDDQNKEVLI
LAAWSHSE

Download         Length: 267 bp

>T134845 NZ_CP042004:7889-8155 [Staphylococcus aureus]
ATGAATCAATATACTGTAAAAATAAAGAATTCAGCAAAATCTGATTTAAAAAAATTAAAACGCTCTCACTTAAAAGAACA
GTTTATTGAAATTATGGAAACATTAAAAAGTAATCCGTATGAAGCTTCACAATCATTTGAGAAGCTAGAACCTAAAAATT
TAAAGAGATATTCAAGAAGAATTAATCATCAACATAGAGTTGTTTATACTGTAGATGATCAGAATAAAGAAGTTTTAATA
TTAGCTGCATGGTCACACTCTGAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9851.93 Da        Isoelectric Point: 4.6158

>AT134845 WP_031838145.1 NZ_CP042004:7632-7889 [Staphylococcus aureus]
MNITNPTDARKDFYQLLKNVNSNHEPIYISGKNTENNAVIIGLKDWKSIQETMYLESTGTMDKVRERERDTSGKTNIEDI
DWDSL

Download         Length: 258 bp

>AT134845 NZ_CP042004:7632-7889 [Staphylococcus aureus]
ATGAATATCACAAACCCAACAGATGCTAGAAAAGACTTTTACCAATTGTTAAAAAACGTAAACAGCAATCATGAACCAAT
TTATATTAGTGGTAAAAATACTGAAAATAATGCTGTTATTATTGGCTTAAAAGATTGGAAGAGTATTCAAGAAACTATGT
ACTTAGAATCAACAGGAACAATGGATAAAGTGAGAGAACGAGAGCGAGATACTAGCGGAAAAACGAATATAGAAGACATT
GATTGGGATAGCCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A499S343

Antitoxin

Source ID Structure
AlphaFold DB A0A499S3X3

References